Cracking Lysine Crotonylation (Kcr): Enlightening a Promising Post‐Translational Modification
Sign Up to like & getrecommendations! Published in 2024 at "Chembiochem"
DOI: 10.1002/cbic.202400639
Abstract: Lysine crotonylation (Kcr) is a recently discovered post‐translational modification (PTM). Both histone and non‐histone Kcr‐proteins have been associated with numerous diseases including cancer, acute kidney injury, HIV latency, and cardiovascular disease. Histone Kcr enhances gene… read more here.
Keywords: crotonylation; kcr; translational modification; crotonylation kcr ... See more keywords
Large-scale lysine crotonylation analysis reveals its potential role in spermiogenesis in the Chinese mitten crab Eriocheir sinensis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2020.103891
Abstract: Lysine crotonylation (Kcr) is a recently-discovered type of post-translational modification. Although Kcr has been reported in many species, little is known about this process in crustaceans. In this study, pan anti-lysine crotonylation antibody enrichment and… read more here.
Keywords: sinensis; kcr; spermiogenesis; lysine crotonylation ... See more keywords
Adapt-Kcr: a novel deep learning framework for accurate prediction of lysine crotonylation sites based on learning embedding features and attention architecture
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac037
Abstract: Protein lysine crotonylation (Kcr) is an important type of posttranslational modification that is associated with a wide range of biological processes. The identification of Kcr sites is critical to better understanding their functional mechanisms. However,… read more here.
Keywords: adapt kcr; kcr; prediction; attention architecture ... See more keywords
Chloroplast crotonylome analysis of wheat seedling leaves reveals the roles of crotonylated proteins involved in salt stress response.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of experimental botany"
DOI: 10.1093/jxb/erad006
Abstract: Lysine crotonylation (Kcr) is a novel post-translational modification. Whether it exists in wheat chloroplasts and what are its functions in salt stress response remain unclear. Here, we performed the first comprehensive chloroplast crotonylome analysis of… read more here.
Keywords: kcr; chloroplast; wheat; stress response ... See more keywords
Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.321054
Abstract: Background: Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as a post-translational histone modification that robustly indicates active promoters. However, the… read more here.
Keywords: kcr; kcr sites; lysine crotonylation; injury ... See more keywords
Identification of the Metabolites of a Novel Anti-MRSA Compound, Kaempferol-3-O-Alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside (KCR), Extracted from American Sycamore
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Communications"
DOI: 10.1177/1934578x1801300321
Abstract: Fractionation of an extract from American sycamore leaves produced the small molecule, kaempferol-3-O-alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside (KCR), which exists in four stereoisomeric forms (EE, EZ, ZE, and ZZ) at the olefin in the p-coumaroyl; all four isomers exhibit… read more here.
Keywords: kcr; rhamnoside kcr; american sycamore; kaempferol alpha ... See more keywords
PlantNh-Kcr: a deep learning model for predicting non-histone crotonylation sites in plants
Sign Up to like & getrecommendations! Published in 2024 at "Plant Methods"
DOI: 10.1186/s13007-024-01157-8
Abstract: Lysine crotonylation (Kcr) is a crucial protein post-translational modification found in histone and non-histone proteins. It plays a pivotal role in regulating diverse biological processes in both animals and plants, including gene transcription and replication,… read more here.
Keywords: plantnh kcr; kcr; model; kcr sites ... See more keywords