Primate-specific 82-kDa choline acetyltransferase attenuates progression of Alzheimer’s disease-like pathology in the APPNL-G-F knock-in mouse model
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DOI: 10.1038/s41598-024-78751-2
Abstract: Alzheimer’s disease (AD) is characterized by amyloidosis, neuroinflammation, cholinergic dysfunction and cognitive impairment. In AD, the cholinergic neuronal marker choline acetyltransferase (ChAT) is reduced and the primate-specific nuclear isoform, 82-kDa ChAT, is mislocalized to cytoplasm.… read more here.
Keywords: alzheimer disease; pathology; kda chat; primate specific ... See more keywords