Hypoxia-activated pro-drugs of the KDAC inhibitor vorinostat (SAHA)
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DOI: 10.1016/j.tet.2020.131170
Abstract: Abstract Hypoxia (lower than normal oxygen) is a characteristic of most solid tumours that results in poor cancer patient prognosis. The difference in cellular environment between normoxia (21% oxygen) or physoxia (4–7.5% oxygen) and hypoxia… read more here.
Keywords: hypoxia; pro drugs; kdac inhibitor; hypoxia activated ... See more keywords