KDEL Receptors: Pathophysiological Functions, Therapeutic Options, and Biotechnological Opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061234
Abstract: KDEL receptors (KDELRs) are ubiquitous seven-transmembrane domain proteins encoded by three mammalian genes. They bind to and retro-transport endoplasmic reticulum (ER)-resident proteins with a C-terminal Lys-Asp-Glu-Leu (KDEL) sequence or variants thereof. In doing this, KDELR… read more here.
Keywords: kdel receptors; receptors pathophysiological; options biotechnological; functions therapeutic ... See more keywords
The Function of KDEL Receptors as UPR Genes in Disease
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22115436
Abstract: The KDEL receptor retrieval pathway is essential for maintaining resident proteins in the endoplasmic reticulum (ER) lumen. ER resident proteins serve a variety of functions, including protein folding and maturation. Perturbations to the lumenal ER… read more here.
Keywords: genes disease; resident proteins; function kdel; kdel receptors ... See more keywords