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   Articles with "kdm1a" as a keyword



KDM1A Acts as an Oncogene and Facilitates the Epithelial Mesenchymal Transition Process in Gastric Cancer

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recommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.70120

Abstract: This study is performed to research the biological role of KDM1A in the epithelial mesenchymal transition (EMT) of gastric cancer and investigate the mechanism involved. read more here.

Keywords: epithelial mesenchymal; kdm1a; gastric cancer; mesenchymal transition ... See more keywords

KDM1A/LSD1 inhibition enhances chemotherapy response in ovarian cancer

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recommendations! Published in 2024 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23792

Abstract: Ovarian cancer (OCa) is the deadliest of all gynecological cancers. The standard treatment for OCa is platinum‐based chemotherapy, such as carboplatin or cisplatin in combination with paclitaxel. Most patients are initially responsive to these treatments;… read more here.

Keywords: treatment; kdm1a lsd1; oca; inhibition ... See more keywords

Capsaicin: A "hot" KDM1A/LSD1 inhibitor from peppers.

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recommendations! Published in 2020 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2020.104161

Abstract: Capsaicinoids are plant secondary metabolites, and capsaicin is the main principal that responsible to the pungency of chili peppers, with widely application as food additive. In our study, capsaicin was characterized as lysine specific demethylase… read more here.

Keywords: capsaicin hot; inhibitor; lsd1 inhibitor; kdm1a ... See more keywords

MicroRNA-325 facilitates atherosclerosis progression by mediating the SREBF1/LXR axis via KDM1A.

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recommendations! Published in 2021 at "Life sciences"

DOI: 10.1016/j.lfs.2021.119464

Abstract: AIMS MicroRNA-325 (miR-325) was significantly upregulated in diabetic atherosclerosis, while its specific role in atherosclerosis has not been established. The present study was set to probe the effects of miR-325 on the atherosclerosis progression and… read more here.

Keywords: microrna 325; mir; kdm1a; mir 325 ... See more keywords

Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-49926-2

Abstract: Transposable elements (TEs) contribute to gene expression regulation by acting as cis-regulatory elements that attract transcription factors and epigenetic regulators. This research aims to explore the functional and clinical implications of transposable element-related molecular events… read more here.

Keywords: hnf4a; transposable elements; hepatocellular carcinoma; expression ... See more keywords

MSC-derived exosomal circMYO9B accelerates diabetic wound healing by promoting angiogenesis through the hnRNPU/CBL/KDM1A/VEGFA axis

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recommendations! Published in 2024 at "Communications Biology"

DOI: 10.1038/s42003-024-07367-z

Abstract: Diabetic foot ulcer (DFU) is a common but devastating complication of diabetes mellitus and might ultimately lead to amputation. Elucidating the regulatory mechanism of wound healing in DFU is quite important for developing DFU management… read more here.

Keywords: vegfa; cbl; wound healing; kdm1a ... See more keywords

DDDR-13. A Brain-Penetrant Epigenetic Strategy to Overcome Therapy-Refractory Glioblastoma

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.0650

Abstract: Glioblastoma (GBM) remains uniformly fatal because the standard temozolomide (TMZ) + radiotherapy regimen is quickly thwarted by epigenetic adaptations that reactivate proliferation and blunt DNA-damage responses; mounting evidence implicates simultaneous up-regulation of lysine-specific demethylase 1… read more here.

Keywords: brain; glioblastoma; brain penetrant; kdm1a ... See more keywords

Deficiency of Kdm1a Induces Locomotor Abnormalities and Learning and Memory Deficits in Zebrafish Larvae.

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recommendations! Published in 2025 at "Journal of integrative neuroscience"

DOI: 10.31083/jin44394

Abstract: BACKGROUND Lysine-Specific Demethylase 1A (Kdm1a) is the first discovered histone lysine-specific demethylase, and mutations in kdm1a have been detected in neurodevelopmental disorders. However, the effect of kdm1a on neurobehaviors and the underlying mechanisms remain largely… read more here.

Keywords: memory deficits; locomotor abnormalities; abnormalities learning; kdm1a ... See more keywords

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer

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recommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2023.1116424

Abstract: Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many… read more here.

Keywords: kdm5b; kdm1a kdm5b; pca; expression ... See more keywords