Articles with "kdm1a lsd1" as a keyword



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Capsaicin: A "hot" KDM1A/LSD1 inhibitor from peppers.

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Published in 2020 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2020.104161

Abstract: Capsaicinoids are plant secondary metabolites, and capsaicin is the main principal that responsible to the pungency of chili peppers, with widely application as food additive. In our study, capsaicin was characterized as lysine specific demethylase… read more here.

Keywords: capsaicin hot; inhibitor; lsd1 inhibitor; kdm1a ... See more keywords
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Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double strand break repair and augments efficacy of temozolomide in glioblastoma.

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Published in 2023 at "Neuro-oncology"

DOI: 10.1093/neuonc/noad018

Abstract: BACKGROUND Efficient DNA repair in response to standard chemo and radiation therapies often contribute to GBM therapy resistance. Understanding the mechanisms of therapy resistance and identifying the drugs that enhance the therapeutic efficacy of standard… read more here.

Keywords: dna; inhibition; kdm1a lsd1; tmz ... See more keywords