HPV16 E6 and E7 upregulate the histone lysine demethylase KDM2B through the c-MYC/miR-146a-5p axys
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-017-0083-1
Abstract: Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an… read more here.
Keywords: demethylase kdm2b; mir 146a; hpv16; cancer ... See more keywords
Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4A, and p57KIP2 transcription
Sign Up to like & getrecommendations! Published in 2018 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmy084
Abstract: H3K4me3 and H3K36me2 histone demethylase KDM2B is an epigenetic regulatory factor involved in cell proliferation in numerous cells including breast cancer cells, however, the regulatory mechanism of KDM2B in cell proliferation of breast cancer cells,… read more here.
Keywords: cell proliferation; p15ink4b p16ink4a; breast cancer; proliferation ... See more keywords
The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000489917
Abstract: Background/Aims: The epigenetic factor KDM2B is a histone demethylase expressed in various tumors. Recently, we have shown that KDM2B regulates actin cytoskeleton organization, small Rho GTPases signaling, cell-cell adhesion and migration of prostate tumor cells.… read more here.
Keywords: tumor cells; colon tumor; small gtpases; kdm2b ... See more keywords