Novel inhibitors of lysine (K)-specific Demethylase 4A with anticancer activity
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DOI: 10.1007/s10637-017-0496-2
Abstract: SummaryLysine (K)-specific demethylase 4A (KDM4A) is a histone demethylase that removes methyl residues from trimethylated or dimethylated histone 3 at lysines 9 and 36. Overexpression of KDM4A is found in various cancer types. To identify… read more here.
Keywords: demethylase; ldd2269; kdm4a; novel inhibitors ... See more keywords
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes
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DOI: 10.1038/s41556-020-0494-z
Abstract: The importance of germline-inherited post-translational histone modifications on priming early mammalian development is just emerging 1 – 4 . Histone H3 lysine 9 (H3K9) trimethylation is associated with heterochromatin and gene repression during cell-fate change… read more here.
Keywords: broad h3k4me3; maternal zygotic; zygotic transition; kdm4a ... See more keywords
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A
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DOI: 10.1038/s41598-020-71403-1
Abstract: Regulatory factor X-5 (RFX5) represents a key transcription regulator of MHCII gene expression in the immune system. This study aims to explore the molecular mechanisms and biological significance of RFX5. Firstly, by analyzing ENCODE chromatin… read more here.
Keywords: rfx5 promotes; kdm4a; progression hepatocellular; rfx5 ... See more keywords
SUMO Modification of Histone Demethylase KDM4A in Kaposi’s Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma
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DOI: 10.1128/jvi.00755-22
Abstract: PEL is an aggressive and untreatable B-cell lymphoma caused by KSHV infection. Therefore, new therapeutic approaches for PEL need to be investigated. ABSTRACT Primary effusion lymphoma (PEL) is a fatal B-cell lymphoma caused by Kaposi’s… read more here.
Keywords: cell; lymphoma; kdm4a; pel cells ... See more keywords
Hypoxia Enhances HIF1α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells International"
DOI: 10.1155/2022/1608806
Abstract: Objective Cervical cancer (CC) is a prevalent cancer in women. Hypoxia plays a critical role in CC cell ferroptosis resistance. This study explored the mechanism of hypoxia in CC cell ferroptosis resistance by regulating HIF1α/KDM4A/H3K9me3.… read more here.
Keywords: ferroptosis resistance; kdm4a; hif1 transcription; hypoxia ... See more keywords
Abstract 4760: KDM4A promotes NEPC progression through regulation of MYC expression
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DOI: 10.1158/1538-7445.am2023-4760
Abstract: Despite advancements in treatment, prostate cancer (PCa) remains the second leading cause of death among men. Neuroendocrine prostate cancer (NEPC) represents one of the most lethal forms of PCa and lacks life-prolonging treatment. Here we… read more here.
Keywords: promotes nepc; nepc progression; kdm4a; kdm4a promotes ... See more keywords
Identification of the histone lysine demethylase KDM4A/JMJD2A as a novel epigenetic target in M1 macrophage polarization induced by oxidized LDL.
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DOI: 10.18632/oncotarget.17748
Abstract: Oxidized low density lipoprotein (oxLDL) induces macrophage activation, an event essential for atherosclerosis. Emerging evidence supports that epigenetic regulation plays important roles in macrophage activation and function. However, it remains unclear which epigenetic modulator is… read more here.
Keywords: polarization; kdm4a; inflammatory; macrophage ... See more keywords