Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype
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DOI: 10.1136/jmedgenet-2021-107747
Abstract: Background Genes involved in epigenetic regulation are central for chromatin structure and gene expression. Specific mutations in these might promote carcinogenesis in several tissue types. Methods We used exome, whole-genome and Sanger sequencing to detect… read more here.
Keywords: histone demethylase; multi cancer; variant; cancer ... See more keywords
KDM4C Contributes to Trophoblast-like Stem Cell Conversion from Porcine-Induced Pluripotent Stem Cells (piPSCs) via Regulating CDX2
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DOI: 10.3390/ijms23147586
Abstract: Studies on ESRRB-regulating porcine-induced pluripotent stem cells (piPSCs) converted to trophoblast-like stem cells (TLSCs) contribute to the understanding of early embryo development. However, the epigenetic modification regulation network during the conversion is poorly understood. Here,… read more here.
Keywords: porcine induced; pluripotent stem; kdm4c; induced pluripotent ... See more keywords
Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury
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DOI: 10.3390/ijms23169318
Abstract: Background: Lysine demethylase 4C (KDM4C) is a nuclear protein that is essential for histone modification and acts as an important regulator of several transcription factors. Previous studies have shown that KDM4C may also play a… read more here.
Keywords: kdm4c; kidney; development; kidney injury ... See more keywords