Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113662
Abstract: Histone lysine demethylase 4D (KDM4D) plays an important role in the regulation of tumorigenesis, progression and drug resistance and has been considered a potential target for cancer treatment. However, there is still a lack of… read more here.
Keywords: potent selective; histone lysine; demethylase kdm4d; kdm4d ... See more keywords
Histone demethylase KDM4D inhibition suppresses renal cancer progression and angiogenesis through JAG1 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death discovery"
DOI: 10.1038/s41420-021-00682-y
Abstract: Kidney cancer, especially clear cell renal cell carcinoma (ccRCC), is one of the representative genitourinary tumors. Investigation of underlying mechanisms of ccRCC development is crucial for patient management. Histone demethylase KDM4D has been reported to… read more here.
Keywords: ccrcc; histone demethylase; cancer; demethylase kdm4d ... See more keywords
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113454119
Abstract: Significance Histone methylation regulates gene transcription through a variety of methylases and demethylases. The regulatory role of autophagy, an important process of protein degradation and recycling, in these histone modifiers is still unclear. We report… read more here.
Keywords: inflammation; kdm4d; histone; autophagic degradation ... See more keywords
The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2055286
Abstract: ABSTRACT Macroautophagy/autophagy is a conserved eukaryotic process to mediate the degradation of cell organelles and protein aggregates, which participates in a variety of cellular responses, including immune signal transduction. KDM4D functions as an important histone… read more here.
Keywords: kdm4d; inhibiting optn; optn mediated; epigenetically regulates ... See more keywords
KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14479
Abstract: OBJECTIVES Stem cells of the apical papilla (SCAPs) provide promising candidates for dental pulp regeneration. Despite great advances in the transcriptional controls of the SCAPs fate, little is known about the regulation of SCAP differentiation.… read more here.
Keywords: kdm4d; osteo dentinogenic; dentinogenic differentiation; migration ... See more keywords