JARID1/KDM5 demethylases as cancer targets?
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2017.1263616
Abstract: In cancer, where the balance between proliferation and differentiation is disturbed, changes in the epigenome occur, some of which present as potential therapeutic targets. Changes in DNA methylation and histone deacetylation have been investigated for… read more here.
Keywords: jarid1 kdm5; kdm5 demethylases; targets jarid1; demethylases cancer ... See more keywords
Functions and Interactions of Mammalian KDM5 Demethylases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.906662
Abstract: Mammalian histone demethylases of the KDM5 family are mediators of gene expression dynamics during developmental, cellular differentiation, and other nuclear processes. They belong to the large group of JmjC domain containing, 2-oxoglutarate (2-OG) dependent oxygenases… read more here.
Keywords: mammalian kdm5; demethylation; interactions mammalian; functions interactions ... See more keywords