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   Articles with "kdm5b" as a keyword



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Targeting histone demethylase KDM5B for cancer treatment.

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recommendations! Published in 2020 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2020.112760

Abstract: KDM5B (Lysine-Specific Demethylase 5B) erases the methyl group from H3K4me2/3, which performs wide regulatory effects on chromatin structure, and represses the transcriptional function of genes. KDM5B functions as an oncogene and associates with human cancers… read more here.

Keywords: histone demethylase; kdm5b; cancer; targeting histone ... See more keywords
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A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2122940119

Abstract: Significance Acute myeloid leukemias (AMLs) with NUP98-NSD1 or MLL abnormality are generally aggressive, demanding a better understanding of the underlying oncogenic mechanisms. We show that these AMLs rely on a regulatory axis involving PRC2–|Kdm5b–|stemness genes… read more here.

Keywords: kdm5b; kdm5b axis; acute myeloid; prc2 kdm5b ... See more keywords
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Awakening KDM5B to defeat leukemia

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2202245119

Abstract: In PNAS, Ren et al. (1) report histone demethylase KDM5B (also called JARID1B or PLU1) as a suppressor of acute myeloid leukemia (AML). AML is one of the most frequently diagnosed adult cancers and is… read more here.

Keywords: kdm5b; aml; leukemia; aml cells ... See more keywords

KDM5B regulates the PTEN/PI3K/Akt pathway to increase sorafenib-resistance in hepatocellular carcinoma

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recommendations! Published in 2022 at "Anti-Cancer Drugs"

DOI: 10.1097/cad.0000000000001329

Abstract: Lysine-specific demethylase 5B (KDM5B) exerts its tumor-promoting functions in numerous malignancies, although the possible mechanisms by which KDM5B promotes cancer aggressiveness in hepatocellular carcinoma (HCC) have been preliminarily explored, the role of this gene in… read more here.

Keywords: kdm5b; pi3k akt; hcc; akt pathway ... See more keywords
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Lysine demethylase KDM5B down‐regulates SIRT3‐mediated mitochondrial glucose and lipid metabolism in diabetic neuropathy

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recommendations! Published in 2022 at "Diabetic Medicine"

DOI: 10.1111/dme.14964

Abstract: Diabetic peripheral neuropathy (DPN) is a common neurological complication of diabetes mellitus without efficient interventions. Both lysine demethylase 5B (KDM5B) and sirtuin‐3 (SIRT3) have been found to regulate islet function and glucose homeostasis. KDM5B was… read more here.

Keywords: kdm5b; kdm5b regulates; demethylase kdm5b; regulates sirt3 ... See more keywords
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KDM5B promotes self‐renewal of hepatocellular carcinoma cells through the microRNA‐448–mediated YTHDF3/ITGA6 axis

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recommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.16342

Abstract: Histone methylation plays important roles in mediating the onset and progression of various cancers, and lysine‐specific demethylase 5B (KDM5B), as a histone demethylase, is reported to be an oncogene in hepatocellular carcinoma (HCC). However, the… read more here.

Keywords: hcc; itga6 axis; ythdf3 itga6; kdm5b ... See more keywords
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Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma

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recommendations! Published in 2018 at "Oncotarget"

DOI: 10.18632/oncotarget.26144

Abstract: Background & aims Hepatocellular carcinoma (HCC) has high potential for recurrence, even in curative operative cases. Although several molecular-targeting drugs have been applied to recurrent HCC, their effectiveness has been limited. This study therefore aims… read more here.

Keywords: hepatocellular carcinoma; hcc; poor prognosis; prognosis ... See more keywords
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The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer

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recommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2023.1116424

Abstract: Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many… read more here.

Keywords: kdm5b; kdm1a kdm5b; pca; expression ... See more keywords