KDM5B promotes metastasis and epithelial–mesenchymal transition via Wnt/β‐catenin pathway in squamous cell carcinoma of the head and neck
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23695
Abstract: Metastasis determines clinical management decision and restricts the therapeutic efficiency in patients with squamous cell carcinoma of the head and neck (SCCHN). Epigenetic factor KDM5B serves as an oncogene in multiple cancers. However, its role… read more here.
Keywords: kdm5b; catenin pathway; scchn; wnt catenin ... See more keywords
Targeting histone demethylase KDM5B for cancer treatment.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112760
Abstract: KDM5B (Lysine-Specific Demethylase 5B) erases the methyl group from H3K4me2/3, which performs wide regulatory effects on chromatin structure, and represses the transcriptional function of genes. KDM5B functions as an oncogene and associates with human cancers… read more here.
Keywords: histone demethylase; kdm5b; cancer; targeting histone ... See more keywords
A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122940119
Abstract: Significance Acute myeloid leukemias (AMLs) with NUP98-NSD1 or MLL abnormality are generally aggressive, demanding a better understanding of the underlying oncogenic mechanisms. We show that these AMLs rely on a regulatory axis involving PRC2–|Kdm5b–|stemness genes… read more here.
Keywords: kdm5b; kdm5b axis; acute myeloid; prc2 kdm5b ... See more keywords
Awakening KDM5B to defeat leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202245119
Abstract: In PNAS, Ren et al. (1) report histone demethylase KDM5B (also called JARID1B or PLU1) as a suppressor of acute myeloid leukemia (AML). AML is one of the most frequently diagnosed adult cancers and is… read more here.
Keywords: kdm5b; aml; leukemia; aml cells ... See more keywords
KDM5B regulates the PTEN/PI3K/Akt pathway to increase sorafenib-resistance in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001329
Abstract: Lysine-specific demethylase 5B (KDM5B) exerts its tumor-promoting functions in numerous malignancies, although the possible mechanisms by which KDM5B promotes cancer aggressiveness in hepatocellular carcinoma (HCC) have been preliminarily explored, the role of this gene in… read more here.
Keywords: kdm5b; pi3k akt; hcc; akt pathway ... See more keywords
Lysine demethylase KDM5B down‐regulates SIRT3‐mediated mitochondrial glucose and lipid metabolism in diabetic neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Diabetic Medicine"
DOI: 10.1111/dme.14964
Abstract: Diabetic peripheral neuropathy (DPN) is a common neurological complication of diabetes mellitus without efficient interventions. Both lysine demethylase 5B (KDM5B) and sirtuin‐3 (SIRT3) have been found to regulate islet function and glucose homeostasis. KDM5B was… read more here.
Keywords: kdm5b; kdm5b regulates; demethylase kdm5b; regulates sirt3 ... See more keywords
KDM5B promotes self‐renewal of hepatocellular carcinoma cells through the microRNA‐448–mediated YTHDF3/ITGA6 axis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16342
Abstract: Histone methylation plays important roles in mediating the onset and progression of various cancers, and lysine‐specific demethylase 5B (KDM5B), as a histone demethylase, is reported to be an oncogene in hepatocellular carcinoma (HCC). However, the… read more here.
Keywords: hcc; itga6 axis; ythdf3 itga6; kdm5b ... See more keywords
Endothelial KDM5B Regulated by Piezo1 Contributes to Disturbed Flow Induced Atherosclerotic Plaque Formation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70237
Abstract: Epigenetic modifications play an important role in disturbed flow (d‐flow) induced atherosclerotic plaque formation. By analysing a scRNA‐seq dataset of the left carotid artery (LCA) under d‐flow conditions, we found that Jarid1b (KDM5B) was upregulated… read more here.
Keywords: flow induced; atherosclerotic plaque; kdm5b; plaque formation ... See more keywords
Abstract 7270: Combination targeting of SKP2 and KDM5B induces senescence in castration-resistant prostate cancer cells via AKT signaling
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7270
Abstract: Prostate cancer (PCa) is the second-leading cause of cancer mortalities and morbidities in the United States and is the most commonly diagnosed malignancy in men. Despite the fact that androgen deprivation therapy is the first-line… read more here.
Keywords: senescence; cancer; kdm5b; prostate cancer ... See more keywords
Abstract 211: Epstein-Barr virus (EBV)‒human host chromatin interactions rearrange spatial DNA genome organisation and hijack KDM5B to distant metastasis proneness in EBV-associated nasopharyngeal carcinoma (NPC)
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-211
Abstract: Epstein-Barr virus (EBV), the first identified human DNA tumour virus, has been detected in nasopharyngeal carcinoma (NPC) over 40 years and over 90% of NPC is strongly associated with EBV infection in the endemic regions.… read more here.
Keywords: kdm5b; distant metastasis; ebv; chromatin interactions ... See more keywords
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Biology Direct"
DOI: 10.1186/s13062-024-00499-6
Abstract: Laryngeal carcinoma (LC) is a common cancer of the respiratory tract. This study aims to investigate the role of RNA-binding motif protein 15 (RBM15) in the cisplatin (DDP) resistance of LC cells. LC-DDP-resistant cells were… read more here.
Keywords: resistance; kdm5b; rbm15; ferroptosis ... See more keywords