A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia
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DOI: 10.1073/pnas.2122940119
Abstract: Significance Acute myeloid leukemias (AMLs) with NUP98-NSD1 or MLL abnormality are generally aggressive, demanding a better understanding of the underlying oncogenic mechanisms. We show that these AMLs rely on a regulatory axis involving PRC2–|Kdm5b–|stemness genes… read more here.
Keywords: kdm5b; kdm5b axis; acute myeloid; prc2 kdm5b ... See more keywords