LncRNA H19 regulates macrophage polarization and promotes Freund's complete adjuvant-induced arthritis by upregulating KDM6A.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107402
Abstract: Aberrant expression of long non-coding RNA (lncRNA) H19 is tightly linked to multiple steps of tumorigenesis via the modulation of cell proliferation and apoptosis; however, the pathological significance and regulatory mechanisms of lncRNA H19 in… read more here.
Keywords: macrophage polarization; lncrna h19; expression; kdm6a ... See more keywords
Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01449-y
Abstract: Aberrations in epigenetic modulation dysregulate transcription, playing a critical role in the developmental process of tumors, including lung cancer. Aberrant levels of the histone 3 lysine-27 demethylase KDM6A have been found in cancer and are… read more here.
Keywords: histone lysine; demethylase kdm6a; role; cancer ... See more keywords
Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112696119
Abstract: Significance This study provides proof-of-principle evidence for intravesical delivery of messenger RNA (mRNA) via a mucoadhesive nanoparticle (NP) strategy and reveals the therapeutic potential of KDM6A in treating bladder cancer metastasis, which remains difficult due… read more here.
Keywords: metastasis; bladder; mrna; intravesical delivery ... See more keywords
CircLDLR Modulates the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Coronary Artery Disease Through miR-26-5p/KDM6A Axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001275
Abstract: Abstract: The purpose of this study was to investigate the effect of circLDLR on the proliferation and apoptosis of vascular smooth muscle cells (VSMCs) in coronary artery disease and its regulatory mechanism. The expression of… read more here.
Keywords: apoptosis; proliferation apoptosis; mir; coronary artery ... See more keywords
X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Science Advances"
DOI: 10.1126/sciadv.aar5598
Abstract: Why are men more likely than women to have cancer? We report that the genetic inequality is an independent intrinsic cause. Men are much more likely than women to develop bladder cancer (BCa), but the… read more here.
Keywords: bladder cancer; chromosome protects; females via; cancer ... See more keywords
Loss of KDM6A/UTX Accelerate the Development of Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-113835
Abstract: In multiple myeloma (MM), inactivating mutations and deletions affecting the histone demethylase KDM6A locus are found in up to 10% of newly diagnosed patients and associated with poor prognosis. KDM6A (also named UTX, Ubiquitously transcribed… read more here.
Keywords: loss kdm6a; multiple myeloma; kdm6a; tumor suppressive ... See more keywords
Lysine-specific demethylase 6A upregulates cadherin-1 and accelerates gastric cancer growth.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666230320100504
Abstract: Background Gastric cancer (GC) ranks fifth among all common malignancies globally. Genetic research has revealed several genes that are frequently dis-regulated in GC, such as lysine-specific demethylase 6A (KDM6A) and cadherin-1 (CDH1). This study aimed… read more here.
Keywords: expression; gastric cancer; specific demethylase; kdm6a ... See more keywords