CRISPR‐mediated knockout of VEGFR2/KDR inhibits cell growth in a squamous thyroid cancer cell line
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DOI: 10.1002/2211-5463.13399
Abstract: Squamous and anaplastic thyroid cancers are the most aggressive and life‐threatening cancer types in humans, with the involvement of lymph nodes in 59% of cases and distant metastases in 26% of cases of all thyroid… read more here.
Keywords: cell; kdr; squamous thyroid; thyroid cancer ... See more keywords
Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.10.003
Abstract: FGF receptors (FGFRs) are tyrosine kinases that are overexpressed in diverse tumors by genetic alterations such as gene amplifications, somatic mutations and translocations. Owing to this characteristic, FGFRs are attractive targets for cancer treatment. It… read more here.
Keywords: novel ponatinib; activity; discovery novel; ponatinib analogues ... See more keywords
Low Levels of Endothelial Progenitor Cells and Their Association with Systemic Inflammation and Monocyte Activation in Older HIV-Infected Men.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2017.0057
Abstract: Endothelial progenitor cells (EPCs) repair damaged vascular endothelium, and low circulating EPC levels have been associated with cardiovascular disease (CVD). CD34+/KDR+ EPCs are commonly reported in the literature and CD34+/CD133+/KDR+ EPCs are rare in circulation… read more here.
Keywords: cd34; hiv; inflammation; cd34 cd133 ... See more keywords
The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20198324
Abstract: The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control… read more here.
Keywords: expression; kdr intrauterine; kdr; intrauterine adhesions ... See more keywords
Oxidase, Esterase, and KDR-Associated Pyrethroid Resistance in Culex quinquefasciatus Field Collections of Collier County, Florida.
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DOI: 10.2987/19-6850.1
Abstract: In several insect species, resistance to pyrethroids and DDT (dichlorodiphenyltrichloroethane) is linked to point mutations in the voltage-gated sodium channel (VGSC) gene. Pyrethroid-based insecticides prolong the opening of sodium channels, causing paralysis known as a… read more here.
Keywords: quinquefasciatus; collier county; resistance; pyrethroid resistance ... See more keywords
KDR (VEGFR2) Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis
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DOI: 10.3390/biom9080355
Abstract: We investigated kinase insert domain-containing receptor (KDR) polymorphisms and protein levels in relation to susceptibility to and severity of Rheumatoid Arthritis (RA). 641 RA patients and 340 controls (HC) were examined for the rs1870377 KDR… read more here.
Keywords: genetic variants; serum levels; rheumatoid arthritis; kdr ... See more keywords