iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
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DOI: 10.1016/j.ccell.2017.09.008
Abstract: Reactive oxygen species (ROS) have emerged as important signaling molecules that play crucial roles in carcinogenesis and cytotoxic responses. Nrf2 is the master regulator of ROS balance. Thus, uncovering mechanisms of Nrf2 regulation is important… read more here.
Keywords: drug resistance; growth drug; keap1 binding; nrf2 keap1 ... See more keywords