Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis
Sign Up to like & getrecommendations! Published in 2017 at "Nature medicine"
DOI: 10.1038/nm.4407
Abstract: Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to define mutations that frequently co-occur… read more here.
Keywords: keap1 loss; lung cancer; cancer; kras driven ... See more keywords
Keap1 Loss Drives Kras-Mutant Lung Cancer and Glutaminolysis Dependency.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-192
Abstract: Loss of Keap1 hyperactivates NRF2 to induce glutaminolysis-dependent Kras-driven lung cancer. read more here.
Keywords: lung cancer; keap1 loss; loss drives; cancer ... See more keywords