Can't KEEP Up: UXS1 Dependency Exposes a Pyrimidine Vulnerability in KEAP1-Mutant Lung Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-25-3547
Abstract: Loss-of-function mutations in KEAP1 are found in more than 20% of non-small cell lung cancers. These mutations stabilize the transcription factor NRF2 to induce a battery of antioxidative and cytoprotective genes. Although NRF2 accumulation promotes… read more here.
Keywords: keap1 mutant; cancer; loss; lung ... See more keywords
Abstract LB014: Targeting Stearoyl-coA desaturase (SCD) as a therapeutic strategy in STK11/KEAP1 co-mutant non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb014
Abstract: Introduction: Non-small cell lung cancer (NSCLC) is a highly prevalent subtype of lung cancer. Recent findings in the field have improved the clinical outcomes for only a subset of patients who are responsive to immunotherapy… read more here.
Keywords: cell; keap1; keap1 mutant; stk11 keap1 ... See more keywords