MicroRNA‐1225 activates Keap1‐Nrf2‐HO‐1 signalling to inhibit TNFα‐induced osteoclastogenesis by mediating ROS generation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3394
Abstract: The influence of miRNA‐1225‐5p (miR‐1225) and Keap1‐Nrf2 signalling on in vitro osteoclast differentiation in mouse models was studied along with the underlying mechanism. In differentiated bone marrow–derived macrophages (BMMs), downregulated miR‐1225 and upregulated Keap1 were… read more here.
Keywords: mir 1225; tnf; keap1 nrf2; ros generation ... See more keywords
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21925
Abstract: The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein… read more here.
Keywords: protein protein; protein interaction; keap1 nrf2; pharmacological properties ... See more keywords
Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8294
Abstract: Spinal cord injury (SCI) is a severe disabling disease that is characterized by inflammation and oxidative reactions. Tangeretin has been shown to possess significant antioxidant and anti‐inflammatory activities. The Keap1/Nrf2 pathway, downstream of the Sesn2… read more here.
Keywords: spinal cord; keap1 nrf2; injury; nrf2 pathway ... See more keywords
KEAP1–NRF2 system regulates age‐related spermatogenesis dysfunction
Sign Up to like & getrecommendations! Published in 2024 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12595
Abstract: The average fatherhood age has been consistently increasing in developed countries. Aging has been identified as a risk factor for male infertility. However, its impact on various mechanisms remains unclear. This study focused on the… read more here.
Keywords: age; age related; nrf2 system; keap1 nrf2 ... See more keywords
NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23796
Abstract: PURPOSE This study identified the function of neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) on bladder cancer (BLCA). METHODS NEDD4L expression in BLCA patients was scrutinized. The function of NEDD4L on the viability, apoptosis,… read more here.
Keywords: p62 keap1; nrf2 pathway; blca; keap1 nrf2 ... See more keywords
Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02539-y
Abstract: Activation of the transcription factor Nrf2 via the Keap1–Nrf2–ARE signaling system regulates the transcription and subsequent expression of cellular cytoprotective proteins and plays a crucial role in preventing pathological conditions exacerbated by the overproduction of… read more here.
Keywords: protein; protein interaction; keap1 nrf2; nrf2 protein ... See more keywords
Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05372-3
Abstract: The association between depression and diabetes has been recognized for many years, but the nature of this relationship remains uncertain. This study investigated the antidepressant-like effect of (p-ClPhSe)2 on mice made diabetic by streptozotocin (STZ)… read more here.
Keywords: keap1 nrf2; pathway; mice; diabetic mice ... See more keywords
Co-treatment Strategy Supports Neuroprotection by Intersecting p62-Keap1-NRF2 and Autophagy Signaling Pathways in the Cellular Model of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2025 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-025-01610-9
Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by neuronal loss, attributed largely to oxidative stress and mitochondrial dysfunction. This study explores the synergistic neuroprotective effects of resveratrol and lithium chloride co-treatment, focusing on… read more here.
Keywords: treatment; signaling pathways; keap1 nrf2; strategy ... See more keywords
LRRK2 Mediates α-Synuclein-Induced Neuroinflammation and Ferroptosis through the p62-Keap1-Nrf2 Pathway in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2025 at "Inflammation"
DOI: 10.1007/s10753-025-02291-8
Abstract: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta and the abnormal aggregation of α-synuclein (α-syn). Despite extensive research,… read more here.
Keywords: ferroptosis; p62 keap1; pathway; keap1 nrf2 ... See more keywords
MicroRNA-141 protects PC12 cells against hypoxia/reoxygenation-induced injury via regulating Keap1-Nrf2 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-019-09804-9
Abstract: To understand the role of microRNA-141 (miR-141) in hypoxia/reoxygenation (H/R)-induced PC12 cell injury via modulation of Keap1/Nrf2 signaling pathway. PC12 cells were divided into Control, H/R, H/R + miR-141 mimics, H/R + NC, H/R + miR-141 inhibitor, H/R + siKeap1 and H/R + miR-141 inhibitors+siKeap1… read more here.
Keywords: cell injury; keap1 nrf2; pc12 cells; mir 141 ... See more keywords
Identification of potential andrographolide-based drug candidate against Keap1-Nrf2 pathway through rigorous cheminformatics screening.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular diversity"
DOI: 10.1007/s11030-022-10435-3
Abstract: The Keap1-Nrf2 [Kelch-like ECH-associated protein-1-Nuclear factor erythroid-2-related factor-2] regulatory pathway plays a vital role in the protection of cells by regulating transcription of antioxidant and detoxification genes. Andrographolide (AGP) regulates the Keap1-Nrf2 pathway by inhibiting… read more here.
Keywords: keap1 protein; agp; drug; nrf2 pathway ... See more keywords