MicroRNA‐1225 activates Keap1‐Nrf2‐HO‐1 signalling to inhibit TNFα‐induced osteoclastogenesis by mediating ROS generation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3394
Abstract: The influence of miRNA‐1225‐5p (miR‐1225) and Keap1‐Nrf2 signalling on in vitro osteoclast differentiation in mouse models was studied along with the underlying mechanism. In differentiated bone marrow–derived macrophages (BMMs), downregulated miR‐1225 and upregulated Keap1 were… read more here.
Keywords: mir 1225; tnf; keap1 nrf2; ros generation ... See more keywords
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21925
Abstract: The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein… read more here.
Keywords: protein protein; protein interaction; keap1 nrf2; pharmacological properties ... See more keywords
NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23796
Abstract: PURPOSE This study identified the function of neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) on bladder cancer (BLCA). METHODS NEDD4L expression in BLCA patients was scrutinized. The function of NEDD4L on the viability, apoptosis,… read more here.
Keywords: p62 keap1; nrf2 pathway; blca; keap1 nrf2 ... See more keywords
Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02539-y
Abstract: Activation of the transcription factor Nrf2 via the Keap1–Nrf2–ARE signaling system regulates the transcription and subsequent expression of cellular cytoprotective proteins and plays a crucial role in preventing pathological conditions exacerbated by the overproduction of… read more here.
Keywords: protein; protein interaction; keap1 nrf2; nrf2 protein ... See more keywords
Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05372-3
Abstract: The association between depression and diabetes has been recognized for many years, but the nature of this relationship remains uncertain. This study investigated the antidepressant-like effect of (p-ClPhSe)2 on mice made diabetic by streptozotocin (STZ)… read more here.
Keywords: keap1 nrf2; pathway; mice; diabetic mice ... See more keywords
MicroRNA-141 protects PC12 cells against hypoxia/reoxygenation-induced injury via regulating Keap1-Nrf2 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-019-09804-9
Abstract: To understand the role of microRNA-141 (miR-141) in hypoxia/reoxygenation (H/R)-induced PC12 cell injury via modulation of Keap1/Nrf2 signaling pathway. PC12 cells were divided into Control, H/R, H/R + miR-141 mimics, H/R + NC, H/R + miR-141 inhibitor, H/R + siKeap1 and H/R + miR-141 inhibitors+siKeap1… read more here.
Keywords: cell injury; keap1 nrf2; pc12 cells; mir 141 ... See more keywords
Identification of potential andrographolide-based drug candidate against Keap1-Nrf2 pathway through rigorous cheminformatics screening.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular diversity"
DOI: 10.1007/s11030-022-10435-3
Abstract: The Keap1-Nrf2 [Kelch-like ECH-associated protein-1-Nuclear factor erythroid-2-related factor-2] regulatory pathway plays a vital role in the protection of cells by regulating transcription of antioxidant and detoxification genes. Andrographolide (AGP) regulates the Keap1-Nrf2 pathway by inhibiting… read more here.
Keywords: keap1 protein; agp; drug; nrf2 pathway ... See more keywords
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-020-09581-7
Abstract: Doxorubicin (DOX) is a widely prescribed anthracycline antineoplastic drug for treating human solid tumors and leukemias. However, DOX therapy is limited by a cumulative, dose-dependent, and irreversible cardiomyopathy that occurs with repeated administration. Presumably, a… read more here.
Keywords: response system; antioxidant response; keap1 nrf2; response ... See more keywords
Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101207
Abstract: In mammals, the Keap1-Nrf2-ARE pathway (henceforth, "the Nrf2 pathway") and autophagy are major intracellular defence systems that combat oxidative damage and maintain homeostasis. p62/SQSTM1, a ubiquitin-binding autophagy receptor protein, links the Nrf2 pathway and autophagy.… read more here.
Keywords: nrf2 pathway; p62 keap1; keap1 nrf2; pathway autophagy ... See more keywords
Activation of Keap1-Nrf2 signaling by 4-octyl itaconate protects human umbilical vein endothelial cells from high glucose.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.12.032
Abstract: High glucose (HG) induces oxidative injury to cultured human umbilical vein endothelial cells (HUVECs). Recent studies have discovered 4-octyl itaconate (OI) as a novel and cell permeable Nrf2 (nuclear-factor-E2-related factor 2) activator. Its potential activity… read more here.
Keywords: keap1 nrf2; vein endothelial; human umbilical; high glucose ... See more keywords
Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.05.028
Abstract: Sleep deprivation (SD) is a hallmark of modern society and associated with many neuropsychiatric disorders, including depression and anxiety. However, the cellular and molecular mechanisms underlying SD-associated depression and anxiety remain elusive. Does the neuroinflammation… read more here.
Keywords: minocycline; sleep deprivation; activation keap1; keap1 nrf2 ... See more keywords