Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
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DOI: 10.1038/ncomms14577
Abstract: NF-E2-related factor-2 (Nrf2) regulates cellular responses to oxidative and electrophilic stress. Loss of Keap1 increases Nrf2 protein levels, and Keap1-null mice die of oesophageal hyperkeratosis because of Nrf2 hyperactivation. Here we show that deletion of… read more here.
Keywords: null mice; hyperactivation; keap1 null; nephrogenic diabetes ... See more keywords