tert‐Butylhydroquinone‐induced formation of high‐molecular‐weight p62: A novel mechanism in the activation of Nrf2‐Keap1
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11849
Abstract: The respiratory system is always exposed to air and is most vulnerable to attack by environmental free radicals. The nuclear factor E2‐related factor 2–Kelch‐like ECH‐associated protein 1–antioxidant response element (Nrf2‐Keap1‐ARE) pathway and p62 are both… read more here.
Keywords: tert butylhydroquinone; keap1 pathway; nrf2 keap1; p62 ... See more keywords
The CncC/keap1 pathway is activated in high temperature-induced metamorphosis and mediates the expression of Cyp450 genes in silkworm, Bombyx mori.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.052
Abstract: Global warming is known to affect the growth, development and reproduction of insects. In this study, the larvae developmental process and endogenous hormone levels under high temperature (36 °C) stress were investigated in the lepidopteran model… read more here.
Keywords: keap1 pathway; temperature; bombyx mori; treatment ... See more keywords
AT‐RVD1 repairs mouse lung after cigarette smoke‐induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.01.045
Abstract: &NA; Long‐term exposure to cigarette smoke (CS) results in alveolar parenchyma destruction due to chronic inflammatory response and the imbalance between oxidants and antioxidants, and proteases and antiproteases. Emphysema is the main symptom of chronic… read more here.
Keywords: keap1 pathway; cigarette smoke; induced emphysema; nrf2 keap1 ... See more keywords
Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
Sign Up to like & getrecommendations! Published in 2017 at "Oncogenesis"
DOI: 10.1038/oncsis.2017.65
Abstract: Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and signaling. Various oncogenic pathways such as proliferation and evading cell death converge on redox-dependent signaling processes. Nrf2 is a key regulator in these… read more here.
Keywords: keap1 pathway; cell proliferation; proliferation; nrf2 keap1 ... See more keywords
Galangin Exhibits Neuroprotective Effects in 6-OHDA-Induced Models of Parkinson’s Disease via the Nrf2/Keap1 Pathway
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DOI: 10.3390/ph15081014
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease, and there is still no cure for it. PD is characterized by the degeneration of dopaminergic neurons, and oxidative stress has been considered an important… read more here.
Keywords: galangin; ohda induced; via nrf2; keap1 pathway ... See more keywords