Negative feedback system to maintain cell ROS homeostasis: KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy
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DOI: 10.1080/15548627.2021.2024702
Abstract: ABSTRACT If cellular reactive oxygen species (ROS) production surpasses the intracellular antioxidant capacity, thus altering the ROS homeostasis, the cell needs to eradicate faulty mitochondria responsible for these excessive ROS. We have shown that even… read more here.
Keywords: pgam5; keap1 pgam5; ros homeostasis; pgam5 complex ... See more keywords