Emodin attenuates CY-induced oxidative injury in PBLs of the blunt snout bream (Megalobrama amblycephala) though the Nrf2-Keap1 signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2021.737201
Abstract: Abstract The present study aimed to evaluate the protective effects of emodin on cyclophosphamide (CY)-induced oxidative injury in peripheral blood leukocytes (PBLs) of blunt snout bream and the potential mechanisms. We examined the cell viability,… read more here.
Keywords: keap1 signaling; pbls; blunt snout; snout bream ... See more keywords
The Effect of Bu Shen Huo Xue Tang on Autoimmune Premature Ovarian Insufficiency via Modulation of the Nrf2/Keap1 Signaling Pathway in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.113996
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Bu Shen Huo Xue Tang (BSHXT) is a traditional Chinese medicine formula that is clinically used in the treatment of premature ovarian insufficiency (POI). However, its therapeutic mechanism remains unclear. AIM OF THE… read more here.
Keywords: autoimmune; keap1 signaling; signaling pathway; nrf2 keap1 ... See more keywords
Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.924817
Abstract: The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in redox homeostasis, which protects cells from stress conditions such as reactive… read more here.
Keywords: cancer oxidative; keap1; nrf2 keap1; keap1 signaling ... See more keywords
Vitamin C Attenuates Oxidative Stress, Inflammation, and Apoptosis Induced by Acute Hypoxia through the Nrf2/Keap1 Signaling Pathway in Gibel Carp (Carassius gibelio)
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DOI: 10.3390/antiox11050935
Abstract: Previous studies have found that vitamin C (VC) has protective effects in fish. However, the efficacy of VC on hypoxia-induced liver injury in fish remains unknown. Therefore, to investigate the protective mechanism of VC on… read more here.
Keywords: nrf2 keap1; acute hypoxia; keap1 signaling; gibel carp ... See more keywords
Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis
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DOI: 10.3390/antiox13101270
Abstract: Periodontitis affects up to 40% of adults over 60 years old and is a consequence of gingivitis. Periodontitis is characterized by a chronic inflammation, periodontal damage, and alveolar bone resorption. The nuclear factor erythroid 2-related… read more here.
Keywords: modulation nrf2; keap1 signaling; periodontitis; signaling phytotherapeutics ... See more keywords