An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors.
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DOI: 10.1021/acschembio.1c00388
Abstract: Inhibiting the Nrf2:Keap1 interaction to trigger cytoprotective gene expression is a promising treatment strategy for oxidative stress-related diseases. A short linear motif from Nrf2 has the potential to directly inhibit this protein-protein interaction, but poor… read more here.
Keywords: keap1 targeted; molecular grafting; integrated molecular; keap1 ... See more keywords