Syndecan-1 regulates extracellular matrix expression in keloid fibroblasts via TGF-β1/Smad and MAPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117326
Abstract: AIMS The present study aimed to explore the effect of syndecan-1 on keloid fibroblasts. MAIN METHODS Immunohistochemistry and Western blot were employed to assess the expression of syndecan-1. Primary cultured keloid fibroblasts were transfected with… read more here.
Keywords: tgf smad; extracellular matrix; keloid; expression ... See more keywords
Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2020.101563
Abstract: AIM Keloid is a benign dermal tumor with excessive hyperplasia and deposition of collagen. As a common tumor suppressor gene, miR-133a-3p has not been studied in keloid. This study will delve into the specific mechanism… read more here.
Keywords: overexpression mir; fibrosis; keloid; proliferation ... See more keywords
Glabridin from Glycyrrhiza glabra Possesses a Therapeutic Role against Keloid via Attenuating PI3K/Akt and Transforming Growth Factor-β1/SMAD Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02045
Abstract: Glabridin (Gla) is a typical flavonoid isolated from the Glycyrrhiza glabra with various bioactivities and is a common additive in many cosmetics. In our study, we evaluated the antiscarring effect of Gla from G. glabra… read more here.
Keywords: role keloid; attenuating pi3k; therapeutic role; glycyrrhiza glabra ... See more keywords
Gene expression profiling analysis: the effect of hydrocortisone on keloid fibroblasts by bioinformatics
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2018.1484559
Abstract: Abstract Background: We aimed to explore potential molecular basis of keloid formation and response mechanism of keloid to hydrocortisone (HC). Methods: Transcriptional profile of GSE7890 which contained five normal scars with no HC treatment (NNHC),… read more here.
Keywords: hydrocortisone; analysis; khc knhc; group ... See more keywords
ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Plastic Surgery and Hand Surgery"
DOI: 10.1080/2000656x.2021.2017944
Abstract: Abstract To investigate the role of a disintegrin and metalloprotease protein 17 (ADAM17) in regulating the proliferation and extracellular matrix (ECM) expression of keloid fibroblasts (KFs) via the epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinase… read more here.
Keywords: proliferation extracellular; proliferation; expression; group ... See more keywords
Calcimycin Suppresses S100A4 Expression and Inhibits the Stimulatory Effect of Transforming Growth Factor &bgr;1 on Keloid Fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Plastic Surgery"
DOI: 10.1097/sap.0000000000001502
Abstract: Abstract Recent researches have indicated that S100A4 participates in tissue fibrosis, whereas calcimycin inhibits this process as a novel S100A4 transcription inhibitor. However, the relationship and mechanisms between calcimycin and S100A4 in keloid fibroblasts (KFs)… read more here.
Keywords: s100a4 expression; transforming growth; bgr; keloid ... See more keywords
Oleanolic acid regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the TGF-β1/SMAD signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cosmetic dermatology"
DOI: 10.1111/jocd.15673
Abstract: BACKGROUND Keloid (KD) is a unique pathological fibroproliferative disease that seriously affects the appearance of patients. This study investigated the effect of oleanolic acid (OA) on the proliferation of keloid fibroblasts (KFs) and the expression… read more here.
Keywords: matrix; proliferation; keloid fibroblasts; tgf ... See more keywords
2-Methoxyestradiol inhibits the proliferation level in keloid fibroblasts through p38 in the MAPK/Erk signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cosmetic dermatology"
DOI: 10.1111/jocd.15810
Abstract: BACKGROUND The MAPK/Erk signaling pathway is a classic pathway in cell proliferation. Our former study showed that keloid tissue revealed a higher proliferation level than physiological scars and normal skin. As a natural metabolite of… read more here.
Keywords: erk signaling; signaling pathway; keloid fibroblasts; mapk erk ... See more keywords
Identifying miRNAs Associated with the Progression of Keloid through mRNA-miRNA Network Analysis and Validating the Targets of miR-29a-3p in Keloid Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/6487989
Abstract: Background Keloid has brought great trouble to people and currently has no uniformly successful treatment. It is urgent to find new targets to effectively prevent the progress of keloid. The current research mainly identifies the… read more here.
Keywords: network; mrna; analysis; mir 29a ... See more keywords
Keloid Core Factor CTRP3 Overexpression Significantly Controlled TGF-β1-Induced Propagation and Migration in Keloid Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "Disease Markers"
DOI: 10.1155/2023/9638322
Abstract: Purpose Keloid is a type of benign fibrous proliferative tumor characterized by excessive scarring. C1q/TNF-related protein 3 (CTRP3) has been proven to possess antifibrotic effect. Here, we explored the role of CTRP3 in keloid. In… read more here.
Keywords: ctrp3; ctrp3 overexpression; tgf induced; keloid ... See more keywords
IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.157091
Abstract: Keloids are considered the manifestation of a fibroproliferative disease characterized by chronic inflammation that is induced following skin injury. Deciphering the underlying mechanism of keloid formation is essential for improving treatment outcomes. Here, we found… read more here.
Keywords: keloid fibrosis; jak stat6; stat6; downregulation ... See more keywords