Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0381-y
Abstract: Keloid is a benign skin tumor characterized by its cell hyperproliferative activity, invasion into normal skin, uncontrolled growth, overproduction and deposition of extracellular matrices and high recurrence rate after various therapies. Nintedanib is a receptor… read more here.
Keywords: nintedanib inhibits; keloid fibroblasts; receptor; phosphorylation ... See more keywords
The mechanisms of β-catenin on keloid fibroblast cells proliferation and apoptosis.
Sign Up to like & getrecommendations! Published in 2018 at "European Review for Medical and Pharmacological Sciences"
DOI: 10.26355/eurrev_201802_14366
Abstract: OBJECTIVE: To investigate the role of β-catenin siRNA on proliferation and apoptosis of keloid fibroblast cell. PATIENTS AND METHODS: Real-time polymerase chain reaction (RT-PCR) and Western blot were performed to monitor the mRNA and protein… read more here.
Keywords: proliferation apoptosis; catenin; tissue; proliferation ... See more keywords