The influence of genistein on free radicals in normal dermal fibroblasts and keloid fibroblasts examined by EPR spectroscopy
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1848-3
Abstract: Normal and keloid fibroblasts were examined using X-band (9.3 GHz) electron paramagnetic resonance spectroscopy. The effect of genistein on the concentration of free radicals in both normal dermal and keloid fibroblasts after ultraviolet irradiation was investigated.… read more here.
Keywords: free radicals; ultraviolet irradiation; keloid fibroblasts; spectroscopy ... See more keywords
Knockdown of FOXM1 inhibits activation of keloid fibroblasts and extracellular matrix production via inhibition of TGF-β1/Smad pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116637
Abstract: Keloid is characterized by overactive fibroblasts. Forkhead box M1 (FOXM1) is transcription factor that plays important roles in the progression of fibrosis. However, the role of FOXM1 in keloid has not been elucidated. In the… read more here.
Keywords: foxm1; tgf; tgf induced; keloid fibroblasts ... See more keywords
Syndecan-1 regulates extracellular matrix expression in keloid fibroblasts via TGF-β1/Smad and MAPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117326
Abstract: AIMS The present study aimed to explore the effect of syndecan-1 on keloid fibroblasts. MAIN METHODS Immunohistochemistry and Western blot were employed to assess the expression of syndecan-1. Primary cultured keloid fibroblasts were transfected with… read more here.
Keywords: tgf smad; extracellular matrix; keloid; expression ... See more keywords
Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2020.101563
Abstract: AIM Keloid is a benign dermal tumor with excessive hyperplasia and deposition of collagen. As a common tumor suppressor gene, miR-133a-3p has not been studied in keloid. This study will delve into the specific mechanism… read more here.
Keywords: overexpression mir; fibrosis; keloid; proliferation ... See more keywords
Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0381-y
Abstract: Keloid is a benign skin tumor characterized by its cell hyperproliferative activity, invasion into normal skin, uncontrolled growth, overproduction and deposition of extracellular matrices and high recurrence rate after various therapies. Nintedanib is a receptor… read more here.
Keywords: nintedanib inhibits; keloid fibroblasts; receptor; phosphorylation ... See more keywords
Molecular response of keloids to ionizing radiation: targeting FOXO1 radiosensitizes keloids
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2121871
Abstract: Abstract Purpose Keloids are benign dermal tumors that arise from abnormal wound healing processes following skin lesions. Surgical excision followed by radiotherapy plays an important role in the treatment of keloids. Nevertheless, radioresistance remains a… read more here.
Keywords: primary keloid; radiation; keloid fibroblasts; response keloids ... See more keywords
A new photodynamic therapy photosensitizer (p1) promotes apoptosis of keloid fibroblasts by targeting caspase-8
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Plastic Surgery and Hand Surgery"
DOI: 10.1080/2000656x.2022.2070181
Abstract: Abstract Photodynamic therapy (PDT) is a new therapy for treating cancer with less toxicity, high selectivity, good cooperativity, and repetitive usability. However, keloid treatment by PDT is mainly focused on clinical appearance, and few studies… read more here.
Keywords: effect; therapy; keloid fibroblasts; photodynamic therapy ... See more keywords
Long-term explant culture: an improved method for consistently harvesting homogeneous populations of keloid fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2014674
Abstract: ABSTRACT Explant culture is a more suitable method than enzyme digestion for the isolation of keloid fibroblasts (KFs), but it has a longer isolation period. In this study, we propose a long-term explant culture method.… read more here.
Keywords: culture; long term; term explant; keloid fibroblasts ... See more keywords
Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2029108
Abstract: ABSTRACT Keloid is a skin disease marked by fibroplasia, and fibroblasts viability plays a considerable part in keloid. Our research was devoted to assessing the involvement and mechanism of circPTPN12 in keloid. The level of… read more here.
Keywords: growth; circptpn12; keloid fibroblasts; mir ... See more keywords
Calcimycin Suppresses S100A4 Expression and Inhibits the Stimulatory Effect of Transforming Growth Factor &bgr;1 on Keloid Fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Plastic Surgery"
DOI: 10.1097/sap.0000000000001502
Abstract: Abstract Recent researches have indicated that S100A4 participates in tissue fibrosis, whereas calcimycin inhibits this process as a novel S100A4 transcription inhibitor. However, the relationship and mechanisms between calcimycin and S100A4 in keloid fibroblasts (KFs)… read more here.
Keywords: s100a4 expression; transforming growth; bgr; keloid ... See more keywords
FBXL6 is dysregulated in keloids and promotes keloid fibroblast growth by inducing c‐Myc expression
Sign Up to like & getrecommendations! Published in 2022 at "International Wound Journal"
DOI: 10.1111/iwj.13847
Abstract: C‐MYC‐mediated keloid fibroblasts proliferation and collagen deposit may contribute to the development of keloids. F‐box and leucine‐rich repeat protein 6 (FBXL6) is reported to be involved in tumour progression, while the role of FBXL6 in… read more here.
Keywords: myc expression; expression fbxl6; fbxl6; expression ... See more keywords