Keloid pathophysiology: fibroblast or inflammatory disorders?
Sign Up to like & getrecommendations! Published in 2019 at "JPRAS Open"
DOI: 10.1016/j.jpra.2019.09.004
Abstract: Background: Keloids are defined as a benign dermal fibroproliferative disorder with no malignant potential. They tend to occur following trivial trauma or any form of trauma in genetically predisposed individuals. Keloids are known to grow… read more here.
Keywords: keloid formation; pathophysiology; inflammatory; pathophysiology fibroblast ... See more keywords
USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-91776-5
Abstract: Spalt-like transcription factor 4 (SALL4) plays a vital role in the progression of many human diseases. However, the role and mechanism of SALL4 regulates in keloid formation remain unclear. The mRNA levels of SALL4 and… read more here.
Keywords: sall4; akt pathway; keloid formation; keloid fibroblast ... See more keywords
From genetics to epigenetics: new insights into keloid scarring
Sign Up to like & getrecommendations! Published in 2017 at "Cell Proliferation"
DOI: 10.1111/cpr.12326
Abstract: Keloid scarring is a dermal fibroproliferative response characterized by excessive and progressive deposition of collagen; aetiology and molecular pathology underlying keloid formation and progression remain unclear. Genetic predisposition is important in the pathogenic processes of… read more here.
Keywords: genetics epigenetics; keloid formation; genetics; epigenetics new ... See more keywords
Macrophages of the M1 and M2 types play a role in keloids pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Wound Journal"
DOI: 10.1111/iwj.13834
Abstract: The pathophysiology of keloid formation is unknown, however, macrophages are thought to play a role in keloid formation. Understanding the mechanism(s) of keloid development might be crucial in developing a new treatment regimen for keloids.… read more here.
Keywords: role; keloid formation; study; play role ... See more keywords
Metabolism, fibrosis, and apoptosis: The effect of lipids and their derivatives on keloid formation
Sign Up to like & getrecommendations! Published in 2024 at "International Wound Journal"
DOI: 10.1111/iwj.14733
Abstract: Keloids, pathological scars resulting from skin trauma, have traditionally posed significant clinical management challenges due to their persistence and high recurrence rates. Our research elucidates the pivotal roles of lipids and their derivatives in keloid… read more here.
Keywords: lipids derivatives; keloid formation; metabolism fibrosis; derivatives keloid ... See more keywords
Keloid Formation and Any Skin Complications in Patients Treated With Isotretinoin and Undergone Any Skin‐Related Procedures
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.16680
Abstract: Isotretinoin is widely used for moderate to severe acne vulgaris. Despite its broad application, isotretinoin carries a risk of permanent scarring and keloid formation following various skin procedures. As a result, a delay of at… read more here.
Keywords: keloid formation; formation skin; skin complications; complications patients ... See more keywords
Different properties of skin of different body sites: The root of keloid formation?
Sign Up to like & getrecommendations! Published in 2017 at "Wound Repair and Regeneration"
DOI: 10.1111/wrr.12574
Abstract: The purpose of this study was to examine extracellular matrix composition, vascularization, and immune cell population of skin sites prone to keloid formation. Keloids remain a complex problem, posing esthetical as well as functional difficulties… read more here.
Keywords: properties skin; extracellular matrix; keloid formation; matrix composition ... See more keywords
Global insights into keloid formation: An international systematic review of regional genetic risk factors and commonalities
Sign Up to like & getrecommendations! Published in 2024 at "Wound Repair and Regeneration"
DOI: 10.1111/wrr.13203
Abstract: Keloid disorder is a morbid and disfiguring benign fibroproliferative disease with a higher incidence in groups with darker skin pigmentation. Predicting keloidogenesis in patients is difficult with treatment primarily aimed at preventing further scar expansion… read more here.
Keywords: insights keloid; review; risk; global insights ... See more keywords
Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway
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DOI: 10.1155/2020/3608372
Abstract: Background Wubeizi (Rhus chinensis Mill.) ointment has been shown as an effective treatment for keloids. However, the protective mechanisms of Wubeizi ointment are not fully understood. The mammalian target of rapamycin (mTOR) has been demonstrated… read more here.
Keywords: formation modulation; keloid formation; mtor; wubeizi ointment ... See more keywords
Specific Non-Coding RNAs Involve in and Regulate the Transcriptional Network during Keloid Formation.
Sign Up to like & getrecommendations! Published in 2025 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2025056805
Abstract: Keloid formation is an undesirable outcome of wound healing and is detrimental to patients' physical and mental health, while the molecular regulators of its pathogenesis, especially non-coding RNAs (ncRNAs), are largely unknown. In this study,… read more here.
Keywords: non coding; coding rnas; keloid formation; network ... See more keywords
KIAA1429 Promotes Keloid Formation Through the TGF-Β1/Smad Pathway.
Sign Up to like & getrecommendations! Published in 2024 at "Current molecular medicine"
DOI: 10.2174/0115665240307157241104095116
Abstract: BACKGROUND Keloid formation is characterized by excessive production of extracellular matrix, leading to dysregulated fibroproliferative collagen response. N6- methyl-adenosine (m6A) modification plays an essential role in this process. OBJECTIVE Our objective in this study was… read more here.
Keywords: tgf smad; smad pathway; keloid formation; formation ... See more keywords