Keratinocyte: A trigger or an executor of psoriasis?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5mr0120-439r
Abstract: Psoriasis is a common chronic inflammatory skin disease characterized by abnormal proliferation/differentiation of keratinocytes and excessive immune cell infiltration in the dermis and epidermis. Over the past 2 decades, immune cells have been considered as… read more here.
Keywords: trigger executor; keratinocyte; psoriasis; keratinocyte trigger ... See more keywords
Cutibacterium acnes regulates the epidermal barrier properties of HPV-KER human immortalized keratinocyte cultures
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69677-6
Abstract: Our skin provides a physical barrier to separate the internal part of our body from the environment. Maintenance of complex barrier functions is achieved through anatomical structures in the skin, the stratified squamous epithelium specialized… read more here.
Keywords: barrier; acnes regulates; cutibacterium acnes; epidermal barrier ... See more keywords
Beta‐catenin non‐canonical pathway: A potential target for inflammatory and hyperproliferative state via expression of transglutaminase 2 in psoriatic skin keratinocyte
Sign Up to like & getrecommendations! Published in 2020 at "Dermatologic Therapy"
DOI: 10.1111/dth.14209
Abstract: Psoriasis is a chronic, local as well as a systemic, inflammatory skin condition. Psoriasis influences the quality of life up to 3.8% of the population and occurs often between 15 and 30 years of age. Specific… read more here.
Keywords: beta catenin; transglutaminase; non canonical; psoriasis ... See more keywords
Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Dermatology"
DOI: 10.1111/exd.14009
Abstract: Differentiation and proliferation of keratinocyte are controlled by various signalling pathways. The epidermal growth factor receptor (EGFR) is known to be an important regulator of multiple epidermal functions. Inhibition of EGFR signalling disturbs keratinocyte proliferation,… read more here.
Keywords: differentiation; differentiation proliferation; keratinocyte; irritant contact ... See more keywords
Keratinocyte EGF signalling dominates in atopic dermatitis lesions: A comparative RNAseq analysis
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14605
Abstract: Atopic dermatitis (AD) remains a highly heterogenous disorder with a multifactorial aetiology. Whilst keratinocytes are known to play a fundamental role in AD, their contribution to the overall immune landscape in moderate‐to‐severe AD is still… read more here.
Keywords: atopic dermatitis; analysis; egf signalling; keratinocyte ... See more keywords
Algorithms for ascertaining keratinocyte carcinomas using health insurance claims and prescription records
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.15490
Abstract: Skin cancer is the most common human malignancy with an ongoing continual increase in global incidence.1-3 Despite their high prevalence, keratinocyte carcinomas (KCs), namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are often… read more here.
Keywords: keratinocyte carcinomas; ascertaining keratinocyte; carcinomas using; algorithms ascertaining ... See more keywords
Prevention versus early detection for long-term control of melanoma and keratinocyte carcinomas: a cost-effectiveness modelling study
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Open"
DOI: 10.1136/bmjopen-2019-034388
Abstract: Objective To compare the long-term economic impact of melanoma prevention by sun protection, with the corresponding impact of early detection of melanoma to decrease melanoma deaths. Design Cost-effectiveness analysis using Markov cohort model. Data were… read more here.
Keywords: melanoma; early detection; long term; prevention ... See more keywords
Combined Transcriptomic Analysis Revealed AKR1B10 Played an Important Role in Psoriasis through the Dysregulated Lipid Pathway and Overproliferation of Keratinocyte
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/8717369
Abstract: RNA-seq has enabled in-depth analysis of the pathogenesis of psoriasis on the transcriptomic level, and many biomarkers have been discovered to be related to the immune response, lipid metabolism, and keratinocyte proliferation. However, few studies… read more here.
Keywords: important role; analysis; overproliferation; psoriasis ... See more keywords
Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.905239
Abstract: Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in keratinocytes. To… read more here.
Keywords: cell; keratinocyte derived; role keratinocyte; psoriasis ... See more keywords
Melanocyte-keratinocyte cross-talk in vitiligo
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1176781
Abstract: Vitiligo is a common acquired pigmentary disorder that presents as progressive loss of melanocytes from the skin. Epidermal melanocytes and keratinocytes are in close proximity to each other, forming a functional and structural unit where… read more here.
Keywords: melanocyte keratinocyte; keratinocyte cross; cross talk; melanocyte ... See more keywords
β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25204640
Abstract: The skin is the largest and a remarkably plastic organ that serves as a protective barrier against environmental stimuli and injuries throughout life. Skin injuries are serious health problems, and wound healing is a critical… read more here.
Keywords: wound healing; cell; wound repair; migration ... See more keywords