Keratinocyte-derived small extracellular vesicles delay diabetic wound healing by triggering fibroblasts autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2024.2358020
Abstract: Abstract Keratinocyte and fibroblast dysfunctions contribute to delayed healing of diabetic wounds. Small extracellular vesicles (sEV) are key mediators of intercellular communication and are involved in the pathogenesis of several diseases. Recent findings suggest that… read more here.
Keywords: extracellular vesicles; diabetic wound; small extracellular; wound healing ... See more keywords
Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2022-222229
Abstract: Objectives S100A9, an alarmin that can form calprotectin (CP) heterodimers with S100A8, is mainly produced by keratinocytes and innate immune cells. The contribution of keratinocyte-derived S100A9 to psoriasis (Ps) and psoriatic arthritis (PsA) was evaluated… read more here.
Keywords: keratinocyte derived; disease; skin joint; derived s100a9 ... See more keywords
Human Keratinocyte-Derived Exosomal MALAT1 Promotes Diabetic Wound Healing by Upregulating MFGE8 via microRNA-1914-3p
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DOI: 10.2147/ijn.s399785
Abstract: Purpose Diabetic wound is a highly prevalent and refractory disease. Extensive studies have confirmed that keratinocytes and macrophages play an important role in the process of wound healing. Additionally, exosomes are regarded as a vital… read more here.
Keywords: derived exosomal; keratinocyte derived; diabetic wound; human keratinocyte ... See more keywords
Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.905239
Abstract: Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in keratinocytes. To… read more here.
Keywords: cell; keratinocyte derived; role keratinocyte; psoriasis ... See more keywords
Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2018.3901
Abstract: Schisandrin B (Sch B), an active extract of Schisandra chinensis, has demonstrated antioxidant activity in a number of in vitro and in vivo models. In the present study, the capacity of Sch B to protect against oxidative injury… read more here.
Keywords: keratinocyte derived; derived hacat; tert butyl; butyl hydroperoxide ... See more keywords