Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation
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DOI: 10.1038/s41598-018-27930-z
Abstract: Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations),… read more here.
Keywords: mitochondrial dna; hypermutation; keratinocyte differentiation;
ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2104718119
Abstract: Significance ΔNp63 is a master regulator of skin homeostasis since it finely controls keratinocyte differentiation and proliferation. Here, we provide cellular and molecular evidence demonstrating the functional role of a ΔNp63 interactor, the R-loop–resolving enzyme… read more here.
Keywords: np63 senataxin; controls keratinocyte; keratinocyte differentiation; transcriptional termination ... See more keywords
Preventative Effects of Antioxidants against PM10 on Serum IgE Concentration, Mast Cell Counts, Inflammatory Cytokines, and Keratinocyte Differentiation Markers in DNCB-Induced Atopic Dermatitis Mouse Model
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DOI: 10.3390/antiox11071334
Abstract: Particulate matter (PM) can cause oxidative stress, inflammation, and skin aging. We investigated the effects of antioxidants such as dieckol, punicalagin, epigallocatechin gallate (EGCG), resveratrol, and Siegesbeckiae Herba extract (SHE) against PM < 10 μm… read more here.
Keywords: keratinocyte differentiation; ige concentration; differentiation markers; mast cell ... See more keywords
Keratin Promotes Differentiation of Keratinocytes Seeded on Collagen/Keratin Hydrogels
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DOI: 10.3390/bioengineering9100559
Abstract: Keratinocytes undergo a complex process of differentiation to form the stratified stratum corneum layer of the skin. In most biomimetic skin models, a 3D hydrogel fabricated out of collagen type I is used to mimic… read more here.
Keywords: collagen hydrogel; keratinocyte differentiation; collagen; keratin ... See more keywords
Epigenetic Mechanisms of Epidermal Differentiation
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DOI: 10.3390/ijms23094874
Abstract: Keratinocyte differentiation is an essential process for epidermal stratification and stratum corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start their differentiation by changing their functional or phenotypical type; this process… read more here.
Keywords: epidermal differentiation; keratinocyte differentiation; epidermal development; mechanisms epidermal ... See more keywords