Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome
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DOI: 10.3390/ijms23105499
Abstract: Hutchinson-Gilford progeria syndrome (HGPS) is a detrimental premature aging disease caused by a point mutation in the human LMNA gene. This mutation results in the abnormal accumulation of a truncated pre-lamin A protein called progerin.… read more here.
Keywords: gilford progeria; hgps ipscs; keratinocytes differentiation; hutchinson gilford ... See more keywords