KRT5 mutation regulate melanin metabolism through Notch signaling pathway between keratinocytes and melanocytes.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental dermatology"
DOI: 10.1111/exd.14761
Abstract: Dowling-Degos disease (DDD) is an autosomal dominant hereditary skin disease characterized by acquired reticular hyperpigmentation in flexural sites, and one of its causative genes is KRT5 gene. But the effect of KRT5, expressed only in… read more here.
Keywords: krt5 mutation; notch signaling; signaling pathway; keratinocytes melanocytes ... See more keywords
Solamargine Alleviated UVB-Induced Inflammation and Melanogenesis in Human Keratinocytes and Melanocytes via the p38 MAPK Signaling Pathway, a Promising Agent for Post-inflammatory Hyperpigmentation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.812653
Abstract: Post-inflammatory hyperpigmentation (PIH) is a common acquired pigmentary disorder occurring after skin inflammation or injury. Ultraviolet B irradiation could exaggerate PIH clinically due to its effect on promoting cutaneous inflammation and melanogenesis in keratinocytes and… read more here.
Keywords: inflammatory hyperpigmentation; inflammation; inflammation melanogenesis; keratinocytes melanocytes ... See more keywords