Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3352
Abstract: Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among patients with major depressive episode remains unknown. Objective To systematically review and meta-analyze data about clinical efficacy and safety for ketamine and ECT in… read more here.
Keywords: review meta; ketamine; depressive episode; patients major ... See more keywords
Ketamine induces apoptosis in lung adenocarcinoma cells by regulating the expression of CD69
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1288
Abstract: Ketamine, an anesthetic, analgesic, or sedative, is widely used for the treatment of cancer pain. Recently, ketamine has been also reported to be tumor repressor for inhibiting proliferation, invasion, and migration, and inducing apoptosis in… read more here.
Keywords: lung adenocarcinoma; apoptosis lung; cd69; apoptosis ... See more keywords
Presence of the ketamine analog of 2-fluorodeschloroketamine residues in wastewater.
Sign Up to like & getrecommendations! Published in 2021 at "Drug testing and analysis"
DOI: 10.1002/dta.3098
Abstract: Ketamine (KET) analogues are increasingly emerging as new psychoactive substances (NPS). The present report describes the first detection of the KET analogue, 2-fluorodeschloroketamine (2F-DCK), in influent samples collected from nine wastewater treatment plants in seven… read more here.
Keywords: fluorodeschloroketamine; ket; ketamine analog; dck ... See more keywords
A critical point in chiral chromatography–mass spectrometry analysis of ketamine metabolites
Sign Up to like & getrecommendations! Published in 2021 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3112
Abstract: Abstract Ketamine is a widely used dissociative drug, whose quantification in plasma and urine can be of pharmacological, toxicological, and clinical interest. Although tandem mass spectrometry allows the reliable determination of ketamine and its metabolites… read more here.
Keywords: ketamine; chiral chromatography; ketamine metabolites; mass spectrometry ... See more keywords
Separation of hydroxynorketamine stereoisomers using capillary electrophoresis with sulfated β‐cyclodextrin and highly sulfated γ‐cyclodextrin
Sign Up to like & getrecommendations! Published in 2017 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201700016
Abstract: The racemic N‐methyl‐d‐aspartate receptor antagonist ketamine is used in anesthesia, analgesia and the treatment of depressive disorders. It is known that interactions of hydroxylated norketamine metabolites and 5,6‐dehydronorketamine (DHNK) with the α7‐nicotinic acetylcholine receptor and… read more here.
Keywords: capillary electrophoresis; ketamine; cyclodextrin highly; electrophoresis ... See more keywords
Enantioselective CE–MS analysis of ketamine metabolites in urine
Sign Up to like & getrecommendations! Published in 2022 at "Electrophoresis"
DOI: 10.1002/elps.202200175
Abstract: The chiral drug ketamine has long‐lasting antidepressant effects with a fast onset and is also suitable to treat patients with therapy‐resistant depression. The metabolite hydroxynorketamine (HNK) plays an important role in the antidepressant mechanism of… read more here.
Keywords: ketamine metabolites; ketamine; enantioselective analysis; chiral selector ... See more keywords
Combination of antiseizure medications phenobarbital, ketamine and midazolam reduces soman-induced epileptogenesis and brain pathology in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia open"
DOI: 10.1002/epi4.12552
Abstract: OBJECTIVE Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABAA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) that may contribute to pharmacoresistance… read more here.
Keywords: ketamine; midazolam; pathology; soman induced ... See more keywords
Rapid electrophoretic monitoring of the anaesthetic ketamine and its metabolite norketamine in rat blood using a contactless conductivity detector to study the pharmacokinetics.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of separation science"
DOI: 10.1002/jssc.201900116
Abstract: A method of capillary electrophoresis with contactless conductivity detection has been developed for non-enantioselective monitoring the anaesthetic ketamine and its main metabolite norketamine. The separation is performed in a 15 μm capillary with an overall length… read more here.
Keywords: monitoring anaesthetic; rat blood; anaesthetic ketamine; ketamine ... See more keywords
Transcriptomic analysis of bladder tissue in a rat model of ketamine‐induced bladder fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24892
Abstract: Ketamine‐induced cystitis (KIC) is a disease caused by ketamine that can cause lower urinary tract symptoms (LUTS). Its end‐stage is bladder contracture, which is related to bladder fibrosis and poses a serious burden to patient… read more here.
Keywords: bladder; ketamine; ketamine induced; bladder fibrosis ... See more keywords
Current approaches for the treatment of ketamine‐induced cystitis
Sign Up to like & getrecommendations! Published in 2023 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.25148
Abstract: Ketamine is a dissociative anesthetic, historically used in a clinical setting for the induction and maintenance of anesthesia. Ketamine usage can produce undesirable psychological manifestations including hallucinations and long‐term psychotomimetic effects. As a results of… read more here.
Keywords: induced cystitis; current approaches; ketamine; ketamine induced ... See more keywords
Anesthetic drugs for rapid sequence intubation: ketamine, but what dose? Author’s reply
Sign Up to like & getrecommendations! Published in 2022 at "Intensive Care Medicine"
DOI: 10.1007/s00134-022-06671-8
Abstract: We greatly appreciate the interest [1] in the dose of ketamine appropriate for anesthetic induction in critically ill patients. There is substantial variability in what could be considered appropriate dosing of ketamine in this setting… read more here.
Keywords: ketamine; rapid sequence; dose; drugs rapid ... See more keywords