Long-term ketamine administration induces bladder damage and upregulates autophagy-associated proteins in bladder smooth muscle tissue.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology"
DOI: 10.1002/tox.23365
Abstract: Long-term ketamine abuse can cause significant lower urinary tract symptoms in humans, termed ketamine-associated cystitis (KC). Here, we established a model of long-term (6 months) ketamine administration in wild-type (C57BL/6) mice. We elucidated the pathological effects… read more here.
Keywords: long term; ketamine administration; term; term ketamine ... See more keywords
Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation–Related Enzymes GSK-3β, CDK5, PP2A, and PP2B in the Mouse Hippocampus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-020-01613-9
Abstract: Ketamine is a recreational drug that causes emotional and cognitive impairments, but its specific mechanisms of action are still unclear. Recent evidence suggests that Tau protein phosphorylation and targeted delivery to the postsynaptic area are… read more here.
Keywords: long term; ketamine administration; ketamine; phosphorylation ... See more keywords
The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.190
Abstract: Ketamine is a non-competitive antagonist at the N-methyl-d-aspartate receptor. It has recently been found to have antidepressant effects and is a drug of abuse, suggesting it may have dopaminergic effects. To examine the effect of… read more here.
Keywords: ketamine administration; analysis; dopamine; effects ketamine ... See more keywords
Increased Reactivity of the Mesolimbic Reward System after Ketamine Injection in Patients with Treatment-resistant Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2019 at "Anesthesiology"
DOI: 10.1097/aln.0000000000002667
Abstract: What We Already Know about This Topic The antidepressant effect of ketamine is associated with increased activity in the reward circuitry of the brain and a suppression of circuitry that mediates perceptual processing of negative… read more here.
Keywords: major depressive; administration; depressive disorder; ketamine administration ... See more keywords
Ketamine administration in idiopathic epileptic and healthy control dogs: Can we detect differences in brain metabolite response with spectroscopy?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.1093267
Abstract: Introduction In recent years ketamine has increasingly become the focus of multimodal emergency management for epileptic seizures. However, little is known about the effect of ketamine on brain metabolites in epileptic patients. Magnetic resonance spectroscopy… read more here.
Keywords: spectroscopy; ketamine; ketamine administration; brain ... See more keywords