Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches.
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DOI: 10.1021/acs.molpharmaceut.8b01214
Abstract: Ketamine is analgesic at anesthetic and subanesthetic doses, and it has been used recently to treat depression. Biotransformation mediates ketamine effects, influencing both systemic elimination and bioactivation. CYP2B6 is the major catalyst of hepatic ketamine… read more here.
Keywords: metabolism; halogen substitution; ketamine analogs; computational approaches ... See more keywords