Ketamine and Etomidate Down-regulate the Hypothalamic-Pituitary-Adrenal Axis in an Endotoxemic Mouse Model.
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DOI: 10.1097/aln.0000000000001704
Abstract: BACKGROUND We compared the effects of etomidate and ketamine on the hypothalamic-pituitary-adrenal axis during sepsis. METHODS Mice (n = 5/group) were injected intraperitoneally with lipopolysaccharide (10 mg/kg) and 6 h later randomized to receive ketamine (100 mg/kg), etomidate… read more here.
Keywords: pituitary adrenal; hypothalamic pituitary; adrenal axis; ketamine etomidate ... See more keywords