Transcriptomic analysis of bladder tissue in a rat model of ketamine‐induced bladder fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24892
Abstract: Ketamine‐induced cystitis (KIC) is a disease caused by ketamine that can cause lower urinary tract symptoms (LUTS). Its end‐stage is bladder contracture, which is related to bladder fibrosis and poses a serious burden to patient… read more here.
Keywords: bladder; ketamine; ketamine induced; bladder fibrosis ... See more keywords
Current approaches for the treatment of ketamine‐induced cystitis
Sign Up to like & getrecommendations! Published in 2023 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.25148
Abstract: Ketamine is a dissociative anesthetic, historically used in a clinical setting for the induction and maintenance of anesthesia. Ketamine usage can produce undesirable psychological manifestations including hallucinations and long‐term psychotomimetic effects. As a results of… read more here.
Keywords: induced cystitis; current approaches; ketamine; ketamine induced ... See more keywords
A randomized, placebo-controlled, phase 1 study to evaluate the effects of TAK-063 on ketamine-induced changes in fMRI BOLD signal in healthy subjects
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05366-1
Abstract: Rationale Phosphodiesterase 10A inhibitor TAK-063 has shown effects that suggest efficacy in schizophrenia treatment. Objective This randomized, double-blind, placebo-controlled, incomplete-crossover study investigated effects of single oral administration of TAK-063 on ketamine-induced changes in blood oxygen… read more here.
Keywords: fmri bold; ketamine induced; bold signal; placebo ... See more keywords
Integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis during postnatal rat retinal development
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113659
Abstract: PURPOSE Remodeling of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) plays a pivotal role for microglia in developing retina. We tested whether integrin-dependent microgliosis mediates ketamine-induced neuronal apoptosis in the developing rat retina. METHODS… read more here.
Keywords: induced neuronal; microgliosis; neuronal apoptosis; ketamine induced ... See more keywords
Blackberry extract improves behavioral and neurochemical dysfunctions in a ketamine-induced rat model of mania
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134566
Abstract: Bipolar disorder is a chronic mood disorder characterized by episodes of mania and depression. The aim of this study was to investigate the effects of blackberry extract on behavioral parameters, oxidative stress and inflammatory markers… read more here.
Keywords: ketamine induced; cerebral cortex; blackberry extract; model mania ... See more keywords
Potential mechanisms for phencyclidine/ketamine-induced brain structural alterations and behavioral consequences.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.12.005
Abstract: Evidence of structural abnormalities in the nervous system of recreational drug [e.g., phencyclidine (PCP) or ketamine] users and/or preclinical animal research models suggests interference with the activity of multiple neurotransmitters, particularly glutamate neurotransmission. The damage… read more here.
Keywords: pcp ketamine; ketamine induced; psa ncam; ketamine ... See more keywords
3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.10.002
Abstract: &NA; The cognitive impairments and negative symptoms experienced by schizophrenia patients still await effective treatment. Alpha7 nicotinic acetylcholine receptors (&agr;7 nAChRs) have gain considerable attention in this regard. It has been recently proposed that positive… read more here.
Keywords: tolyl acrylamide; furan tolyl; ketamine induced; cognitive impairments ... See more keywords
Nicotinic Acetylcholine Receptors are Associated with Ketamine-induced Neuronal Apoptosis in the Developing Rat Retina
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.01.057
Abstract: Early synchronized spontaneous network activity is a hallmark of the brain growth spurt period, during which general anesthetics cause widespread neuronal apoptosis and subsequent cognitive dysfunction. However, the relationship of such activity to anesthetic-induced neuronal… read more here.
Keywords: induced neuronal; ketamine induced; apoptosis; neuronal apoptosis ... See more keywords
Neonatal inhibition of Na+-K+-2Cl--cotransporter prevents ketamine induced spatial learning and memory impairments.
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2016.11.001
Abstract: Prolonged ketamine exposure in neonates at anesthetic doses is known to cause long-term impairments of learning and memory. A current theoretical mechanism explains this phenomenon as being neuro-excitotoxicity mediated by compensatory upregulation of N-methyl-d-aspartate receptors… read more here.
Keywords: ketamine induced; neonatal inhibition; inhibition 2cl; learning memory ... See more keywords
Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression
Sign Up to like & getrecommendations! Published in 2018 at "Molecular psychiatry"
DOI: 10.1038/mp.2017.58
Abstract: The mechanisms of action of the rapid antidepressant effects of ketamine, an N-methyl-D-aspartate glutamate receptor antagonist, have not been fully elucidated. This study examined the effects of ketamine on ligand binding to a metabotropic glutamatergic… read more here.
Keywords: reduction; mglur5; ketamine induced; mglur5 availability ... See more keywords
Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.6
Abstract: There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity suggests that facilitation… read more here.
Keywords: verbal learning; ketamine induced; ketamine; learning memory ... See more keywords