Mechanistic Target of Rapamycin–Independent Antidepressant Effects of (R)-Ketamine in a Social Defeat Stress Model
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.05.016
Abstract: BACKGROUND The role of the mechanistic target of rapamycin (mTOR) signaling in the antidepressant effects of ketamine is controversial. In addition to mTOR, extracellular signal-regulated kinase (ERK) is a key signaling molecule in prominent pathways… read more here.
Keywords: effects ketamine; model; ketamine ketamine; mtor ... See more keywords
Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness and neurocognitive performance in healthy volunteers
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.01.005
Abstract: Ketamine and its (S)-enantiomer show distinct psychological effects that are investigated in psychiatric research. Its antidepressant activity may depend on the extent and quality of these psychological effects which may greatly differ between the enantiomers.… read more here.
Keywords: ketamine; effects ketamine; ketamine ketamine; compared ketamine ... See more keywords
Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats
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DOI: 10.1016/j.pbb.2020.173011
Abstract: Although (S)-ketamine was approved for use in treatment-resistant patients in 2019, new preclinical findings suggest that (R)-ketamine might produce better efficacy and tolerability relative to (S)-ketamine. Here we evaluated the effects of (R)-, (S)-, and… read more here.
Keywords: ketamine; stimulus effects; discriminative stimulus; effects ketamine ... See more keywords
Total intravenous anesthesia with propofol associated or not with remifentanil, ketamine, or S-ketamine for laparoscopic ovariectomy in female dogs.
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DOI: 10.1016/j.tcam.2021.100575
Abstract: Total intravenous anesthesia (TIVA) has been gaining ground in the routine of small animals. This study aimed to evaluate the hemodynamic effects produced by continuous infusion of propofol isolated or associated with ketamine, S-ketamine, or… read more here.
Keywords: propofol; total intravenous; ketamine; ketamine ketamine ... See more keywords
Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01447-4
Abstract: TO THE EDITOR: We read with interest the article by Bonaventura et al. [1], who investigated the pharmacological properties of subanesthetic doses of ketamine enantiomers in rats and compared each enantiomer using rodent models of… read more here.
Keywords: bonaventura; ketamine; ketamine ketamine; ratio ... See more keywords