Optimisation of ketamine‐xylazine anaesthetic dose and its association with changes in the dendritic spine of CA1 hippocampus in the young and old male and female Wistar rats
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.936
Abstract: Abstract Background A combination of ketamine‐xylazine (K‐X) is frequently used for anaesthesia in rats. Sex and age affect this cocktail dosage. Ketamine causes a hypnotic effect by blocking NMDA receptors located on the dendritic spine… read more here.
Keywords: ketamine xylazine; spine ca1; spine; dendritic spine ... See more keywords
Non-invasive visual evoked potentials under sevoflurane versus ketamine-xylazine in rats
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e08360
Abstract: Background Visual Evoked Potential (VEP) quantifies electrical signals produced in visual cortex in response to visual stimuli. VEP elicited by light flashes is a useful biomarker to evaluate visual function in preclinical models and it… read more here.
Keywords: visual evoked; ketamine xylazine; non invasive; xylazine ... See more keywords
Ketamine-xylazine anesthesia depth affects auditory neuronal responses in the lateral superior olive complex of the gerbil.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurophysiology"
DOI: 10.1152/jn.00217.2021
Abstract: Studies of in vivo neuronal responses to auditory inputs in the superior olive complex (SOC) are usually done under anesthesia. However, little attention has been paid to the effect of anesthesia itself on response properties.… read more here.
Keywords: anesthesia depth; anesthesia; ketamine xylazine; neuronal responses ... See more keywords
Ketamine/Xylazine Anesthesia–Related Corneal Lesions in Rats With Surgically Implanted Venous Catheters Utilized in Nonclinical Intravenous Studies
Sign Up to like & getrecommendations! Published in 2020 at "Toxicologic Pathology"
DOI: 10.1177/0192623320960705
Abstract: Nonclinical rodent studies with repeat slow intravenous dosing, such as safety assessments of anticancer therapeutics, often require the use of animals with surgically implanted catheters. Catheterization is a relatively short surgical procedure but requires use… read more here.
Keywords: related corneal; surgically implanted; ketamine xylazine; xylazine anesthesia ... See more keywords
Anesthetic effects and body weight changes associated with ketamine-xylazine-lidocaine administered to CD-1 mice
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0184911
Abstract: Anesthesia for mice is commonly performed through the injection of parenteral agents via the intraperitoneal (IP) route. Variability in anesthetic sensitivities has been noted in mice resulting in inconsistencies in anesthetic depth and/or mortality. Anesthetic… read more here.
Keywords: ketamine xylazine; mice; xylazine lidocaine; xylazine ... See more keywords
Impact of repeated anesthesia with ketamine and xylazine on the well-being of C57BL/6JRj mice
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0203559
Abstract: Within the scope of the 3Rs of Russel and Burch, the number of laboratory animals can be reduced by repeated use of an animal. This strategy only becomes relevant, if the total amount of pain,… read more here.
Keywords: repeated anesthesia; impact; ketamine xylazine; c57bl 6jrj ... See more keywords
Protective roles of ketamine and xylazine against lightinduced retinal degeneration in rats
Sign Up to like & getrecommendations! Published in 2021 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v18i4.7
Abstract: Purpose: To study the protective effects of ketamine and xylazine against light exposure-induced retinal degeneration (RD) in rats. Methods: Sprague Dawley rats were divided into three groups viz: light damage before anesthesia (LAE), light damage… read more here.
Keywords: damage; anesthesia; immunochemistry; ketamine xylazine ... See more keywords