Copper-Catalyzed Umpolung of N-2,2,2-Trifluoroethylisatin Ketimines for the Enantioselective 1,3-Dipolar Cycloaddition with Benzo[b]thiophene Sulfones.
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DOI: 10.1021/acs.orglett.2c01716
Abstract: A copper-catalyzed umpolung of N-2,2,2-trifluoroethylisatin ketimines for the enantioselective 1,3-dipolar cycloaddition with benzo[b]thiophene sulfones was developed. Using a catalyst system consisting of an (S,Sp)-tBu-Phosferrox ligand, Cu(OTf)2, and Cs2CO3, a range of pentacyclic spirooxindoles containing pyrrolidine… read more here.
Keywords: ketimines enantioselective; trifluoroethylisatin ketimines; catalyzed umpolung; umpolung trifluoroethylisatin ... See more keywords