Construction of Acyclic Quaternary Stereocenters via Mannich-Type Addition of α,α-Disubstituted N-tert-Butanesulfinyl Ketimines to Isatin-Derived Ketimines.
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DOI: 10.1021/acs.orglett.2c00888
Abstract: A Mannich reaction of deprotonated, highly enantioenriched α,α-disubstituted N-tert-butanesulfinyl ketimines with isatin-derived ketimines was developed to prepare 3-amino-3-substituted oxindoles bearing an acyclic quaternary stereogenic carbon substituted with two sterically similar groups. The excellent stereocontrol of… read more here.
Keywords: butanesulfinyl ketimines; ketimines isatin; disubstituted tert; tert butanesulfinyl ... See more keywords