Visible-light-Induced Oxidative a-keto-Dichlorination of Arylalkynes by CuCl2 at Room Temperature.
Sign Up to like & getrecommendations! Published in 2022 at "ChemSusChem"
DOI: 10.1002/cssc.202200957
Abstract: We have developed a visible light-induced oxidative a-keto-dichlorination of terminal and internal aryl alkynes to form dichloroacetophenones (DCAPs) and dichlorophenyl-acetophenones (DCPAPs), respectively, by using CuCl 2 as a photoredox catalyst in the presence of air… read more here.
Keywords: light induced; keto dichlorination; induced oxidative; keto ... See more keywords
Diurnal photodegradation of fluorinated diketones (FDKs) by OH radicals using different atmospheric simulation chambers: Role of keto-enol tautomerization on reactivity.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.131562
Abstract: Rate coefficients for the gas-phase reactions of OH radicals with a series of fluorinated diketones have been determined for the first time at (298 ± 3) K and atmospheric pressure using the relative method and FTIR spectroscopy… read more here.
Keywords: tautomerization; keto; role; fluorinated diketones ... See more keywords
Biochemical and structural characterization of L-2-keto-3-deoxyarabinonate dehydratase: A unique catalytic mechanism in the Class I aldolase protein superfamily.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00515
Abstract: L-2-Keto-3-deoxyarabinonate (L-KDA) dehydratase (AraD) catalyzes the hydration of L-KDA to α-ketoglutaric semialdehyde in the non-phosphorylative L-arabinose pathway from bacteria, and belongs to the dihydrodipicolinate synthase (DHDPS)/N-acetylneuraminate lyase (NAL) protein superfamily. All members of this superfamily,… read more here.
Keywords: catalytic mechanism; keto deoxyarabinonate; dehydratase; keto ... See more keywords
One-Pot Biosynthesis of 2-Keto-4-hydroxybutyrate from Cheap C1 Compounds Using Rationally Designed Pyruvate Aldolase and Methanol Dehydrogenase.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c09108
Abstract: One-carbon chemicals (C 1s) are potential building blocks as they are cheap, sustainable, and abiotic components. Methanol-derived formaldehyde can be another versatile building block for the production of 2-keto-4-hydroxyacid derivatives that can be used for… read more here.
Keywords: methanol dehydrogenase; keto hydroxybutyrate; one pot; aldolase ... See more keywords
Nickel-Catalyzed Asymmetric Hydrogenation of γ-Keto Acids, Esters, and Amides to Chiral γ-Lactones and γ-Hydroxy Acid Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00826
Abstract: A highly efficient asymmetric hydrogenation of a series of γ-keto acid derivatives, including γ-keto acids, esters, and amides, using a Ni-(R,R)-QuinoxP* complex as the catalyst has been developed to afford chiral γ-hydroxy acid derivatives with… read more here.
Keywords: esters amides; asymmetric hydrogenation; acids esters; keto ... See more keywords
Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01302
Abstract: A novel decarbonylative coupling of α-keto acids and ynamides with extrusion of CO for synthesis of β-keto imides is reported. This process features mild reaction conditions, a broad substrate scope, and high efficiency. An isotope-labeling… read more here.
Keywords: decarbonylative coupling; acids ynamides; synthesis keto; keto ... See more keywords
Improved Subcutaneous Delivery of Ketoconazole Using EpiDerm and HSPiP Software-Based Simulations as Assessed by Cell Viability, Cellular Uptake, Permeation, and Hemolysis In Vitro Studies
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c06001
Abstract: Ketoconazole (KETO) is the drug of choice to control local, systemic, and resistant types of fungal infections. Subcutaneous (sub-Q) delivery offers several benefits. The present study investigated the sub-Q delivery of KETO using HSPiP software… read more here.
Keywords: hemolysis; hspip; permeation; keto ... See more keywords
Pyrimidine Nucleosides with a Reactive (β-Chlorovinyl)sulfone or (β-Keto)sulfone Group at the C5 Position, Their Reactions with Nucleophiles and Electrophiles, and Their Polymerase-Catalyzed Incorporation into DNA
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b00584
Abstract: Transition-metal-catalyzed chlorosulfonylation of 5-ethynylpyrimidine nucleosides provided (E)-5-(β-chlorovinyl)sulfones A, which undergo nucleophilic substitution with amines or thiols affording B. The treatment of vinyl sulfones A with ammonia followed by acid-catalyzed hydrolysis of the intermediary β-sulfonylvinylamines gave… read more here.
Keywords: nucleosides reactive; dna; sulfone; pyrimidine nucleosides ... See more keywords
The enzymatic epimerization of deoxynivalenol by Devosia mutans proceeds through the formation of 3-keto-DON intermediate
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07319-0
Abstract: The enzymatic detoxification of deoxynivalenol (DON) is a promising mitigation strategy for addressing this mycotoxin contamination of cereal grains. A recently described bacterium, Devosia mutans 17-2-E-8, capable of transforming DON into its non-toxic stereoisomer 3-epi-DON,… read more here.
Keywords: devosia mutans; keto intermediate; deoxynivalenol; epimerization ... See more keywords
Synthesis of β-keto sulfones via a multicomponent reaction through sulfonylation and decarboxylation
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00026j
Abstract: A copper(I)-catalyzed synthesis of β-keto sulfones through a multicomponent reaction of aryldiazonium tetrafluoroborates, 3-arylpropiolic acids, sulfur dioxide, and water was developed. This reaction proceeds through a tandem radical process, and the sulfonyl radical, generated from… read more here.
Keywords: multicomponent reaction; sulfonylation decarboxylation; synthesis keto; keto ... See more keywords
The role of S-bond in tenoxicam keto–enolic tautomerization
Sign Up to like & getrecommendations! Published in 2019 at "CrystEngComm"
DOI: 10.1039/c9ce00874h
Abstract: A non-covalent interaction between the sulphur atom of thiophenyl moiety and oxygen of the carbonyl group (S-bond) plays a crucial role in keto–enol tautomerization of tenoxicam leading to the crystallization of latter only in zwitterionic… read more here.
Keywords: role bond; keto; tautomerization; keto enolic ... See more keywords