Enzymatic Production of Opine‐Type Chiral Amines with Controlled Stereoselectivity
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DOI: 10.1002/cctc.202402066
Abstract: Chiral secondary amine dicarboxylic acid derivatives are key building blocks of several peptidomimetic angiotensin‐converting enzyme (ACE2) inhibitors. Reductive amination of α‐keto acids with α‐amino esters can yield orthogonally functionalized derivatives facilitating further chemical modifications. Biocatalysis… read more here.
Keywords: production opine; enzymatic production; keto acids; amino esters ... See more keywords
Photoinduced, Decarboxylative Coupling of α‐Keto Acids with Diselenides to Form Selenoesters
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DOI: 10.1002/ejoc.202401399
Abstract: A mild and green strategy for the synthesis of selenoester derivatives has been developed through photoinduced decarboxylative coupling of α‐keto acids with diselenides. This transformation proceeds smoothly without requiring any external photocatalyst, additive, or oxidant.… read more here.
Keywords: acids diselenides; coupling keto; decarboxylative coupling; keto acids ... See more keywords
Reversibility of the catalytic ketonization of carboxylic acids and of beta-keto acids decarboxylation
Sign Up to like & getrecommendations! Published in 2018 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2018.04.002
Abstract: Abstract Decarboxylation of beta-keto acids in enzymatic and heterogeneous catalysis has been considered in the literature as an irreversible reaction due to a large positive entropy change. We report here experimental evidence for its reversibility… read more here.
Keywords: reversibility; beta keto; decarboxylation; carboxylic acids ... See more keywords
Synthesis of quinazolin-4(3H)-ones via electrochemical decarboxylative cyclization of α‑keto acids with 2-aminobenzamides
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2020.111345
Abstract: Abstract Herein, an environmentally benign electrochemical protocol has been disclosed for the synthesis of quinazolin-4(3H)-one derivatives from readily available α‑keto acids and 2-aminobenzamides. This decarboxylative cyclization process proceeds conveniently in the absence of any homogeneous… read more here.
Keywords: synthesis quinazolin; decarboxylative cyclization; acids aminobenzamides; keto acids ... See more keywords
Nickel-Catalyzed Asymmetric Hydrogenation of γ-Keto Acids, Esters, and Amides to Chiral γ-Lactones and γ-Hydroxy Acid Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00826
Abstract: A highly efficient asymmetric hydrogenation of a series of γ-keto acid derivatives, including γ-keto acids, esters, and amides, using a Ni-(R,R)-QuinoxP* complex as the catalyst has been developed to afford chiral γ-hydroxy acid derivatives with… read more here.
Keywords: esters amides; asymmetric hydrogenation; acids esters; keto ... See more keywords
Calcium(II)-Catalyzed Reductive Amination of Biomass-Derived Keto Acids to Functionalized Lactams under Solvent-Free Conditions.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00676
Abstract: Direct access to the polyfluorinated lactams through Ca(NTf2)2 catalyzed by either the reductive amination of biomass-derived keto acids with amines or the reductive amination of amino acids with carbonyl derivatives under solvent-free conditions is realized.… read more here.
Keywords: biomass derived; amination biomass; derived keto; reductive amination ... See more keywords
Visible-Light-Induced Decarboxylative Annulation of α,β-Unsaturated Acids with Amines and α-Keto Acids for 2,4-Diarylquinoline Synthesis.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c00099
Abstract: An efficient and sustainable approach for the synthesis of 2,4-diarylquinolines has been developed via a visible-light-promoted metal-free three-component decarboxylative annulation pathway. This one-pot protocol combines readily available feed-stock α,β-unsaturated acids, aromatic amines, and α-keto acids… read more here.
Keywords: annulation; visible light; unsaturated acids; decarboxylative annulation ... See more keywords
Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01302
Abstract: A novel decarbonylative coupling of α-keto acids and ynamides with extrusion of CO for synthesis of β-keto imides is reported. This process features mild reaction conditions, a broad substrate scope, and high efficiency. An isotope-labeling… read more here.
Keywords: decarbonylative coupling; acids ynamides; synthesis keto; keto ... See more keywords