Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate †
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DOI: 10.3390/molecules24193477
Abstract: The total synthesis of (+)-10-keto-oxycodone was attained from phenethyl acetate in a stereoselective manner. Absolute stereochemistry was established via enzymatic dihydroxylation of phenethyl acetate with the recombinant strain JM109 (pDTG601A) that furnished the corresponding cis-cyclohexadienediol… read more here.
Keywords: total synthesis; phenethyl acetate; synthesis keto; keto ... See more keywords