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Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-98788-0_13
Abstract: Aldose reductase (AR) is an NADPH-dependent aldo-keto reductase that has been shown to be involved in the pathogenesis of several blinding diseases such as uveitis, diabetic retinopathy (DR) and cataract. However, possible mechanisms linking the…
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Keywords:
aldo keto;
multifunctional proteins;
keto reductases;
therapeutic targets ... See more keywords
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Published in 2017 at "Cellular Oncology"
DOI: 10.1007/s13402-017-0351-7
Abstract: PurposeAldo-keto reductases (including AKR1B1 and AKR1B10) constitute a family of oxidoreductases that have been implicated in the pathophysiology of diabetes and cancer, including colorectal cancer (CRC). Available data indicate that, despite their similarities in structure…
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Keywords:
keto reductases;
colorectal cancer;
expression;
akr1b1 akr1b10 ... See more keywords
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Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00337
Abstract: 1-Nitropyrene (1-NP) is a constituent of diesel exhaust and classified as a group 2A probable human carcinogen. The metabolic activation of 1-NP by nitroreduction generates electrophiles that can covalently bind DNA to form mutations to…
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Keywords:
metabolic activation;
keto reductases;
factor;
nitroreduction ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27133981
Abstract: Both members of the aldo-keto reductases (AKRs) family, AKR1B1 and AKR1B10, are over-expressed in various type of cancer, making them potential targets for inflammation-mediated cancers such as colon, lung, breast, and prostate cancers. This is…
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Keywords:
software;
aldo keto;
phenylcarbamoylazinane triazole;
keto reductases ... See more keywords