Identification of Gut Bacterial Enzymes for Keto-Reductive Metabolism of Xenobiotics.
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DOI: 10.1021/acschembio.2c00312
Abstract: Human gastrointestinal microbiota are known for the keto-reductive metabolism of small-molecule pharmaceuticals; however, the responsible enzymes remain poorly understood. Through in vitro biochemical assays, we report the identification of enzymes encoded in the genome of… read more here.
Keywords: reductive metabolism; gut bacterial; identification gut; keto reductive ... See more keywords