An insight into the interaction between α-ketoamide- based inhibitor and coronavirus main protease: A detailed in silico study
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical Chemistry"
DOI: 10.1016/j.bpc.2020.106510
Abstract: The search for therapeutic drugs that can neutralize the effects of COVID-2019 (SARS-CoV-2) infection is the main focus of current research. The coronavirus main protease (Mpro) is an attractive target for anti-coronavirus drug design. Further,… read more here.
Keywords: inhibitor; based inhibitor; coronavirus main; main protease ... See more keywords
COVID-19: In silico identification of potent α-ketoamide inhibitors targeting the main protease of the SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130897
Abstract: The COVID-19 has been creating a global crisis, causing countless deaths and unbearable panic. Despite the progress made in the development of the vaccine, there is an urge need for the discovery of antivirals that… read more here.
Keywords: model; main protease; pharmacophore fit; sars cov ... See more keywords
Perspectives on the design and discovery of α-ketoamide inhibitors for the treatment of novel coronavirus: where do we stand and where do we go?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2052847
Abstract: ABSTRACT Introduction The main cysteine protease from SARS-CoV-2 (Mpro), conserved among many pathogenic coronaviruses, represents a recently validated antiviral drug target, with at least one inhibitor recently approved for clinical use as an antiviral drug,… read more here.
Keywords: ketoamide inhibitors; cov mpro; ketoamide; drug ... See more keywords