Articles with "ketocarboxylic acids" as a keyword



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Asymmetric Synthesis of α-Chloro-α-halo Ketones by Decarboxylative Chlorination of α-Halo-β-ketocarboxylic Acids

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Published in 2019 at "Synthesis"

DOI: 10.1055/s-0039-1690009

Abstract: Chiral α-chloro-α-fluoro ketones were synthesized by enantio­selective decarboxylative chlorination of α-chloro-β-ketocarboxylic acids in the presence of a chiral amine catalyst. The reaction yielded the corresponding α-chloro-α-fluoro ketones with moderate-to-high enantioselectivity (up to 90% ee). The… read more here.

Keywords: halo; synthesis; ketocarboxylic acids; decarboxylative chlorination ... See more keywords