The Influence of Different Triazole Antifungal Agents on the Pharmacokinetics of Cyclophosphamide
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DOI: 10.1177/1060028019896894
Abstract: Background: Cyclophosphamide is one of the most important chemotherapeutic drugs. Known as a widely accepted treatment strategy, chemotherapy may damage the immune function of cancer patients; as a result, invasive fungal infections (IFIs) occur. Triazole… read more here.
Keywords: antifungal agents; ketoconazole; triazole antifungal; pharmacokinetics cyclophosphamide ... See more keywords
Low-level Electrochemical Analysis of Ketoconazole by Sepiolite Nanoparticles Modified Sensor in Shampoo Sample.
Sign Up to like & getrecommendations! Published in 2020 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2019.5398
Abstract: In this study, the nano-sepiolite modified carbon paste electrode (CCPE) was prepared for the determination of ketoconazole (KC). The effects of pH, the proportion of the electrode modifier, deposition potential, and deposition time were investigated.… read more here.
Keywords: ketoconazole; analysis; shampoo; level electrochemical ... See more keywords
Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03
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DOI: 10.2139/ssrn.3377550
Abstract: Background Granulosa cell ovarian tumor (GCT) is characterized by a pathognomonic mutation in the FOXL2 gene (402 C > G) that leads to an overactivation of steroidogenesis. CYP17 is a key enzyme in such process and can… read more here.
Keywords: oncology; cell ovarian; trial; granulosa cell ... See more keywords
Formulation and Development of Hyaluronic Acid based gel with Ketoconazole -Loaded Nanostructured Lipid Carriers in Fungal Infection.
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DOI: 10.2174/2211738511666230310103017
Abstract: BACKGROUND Ketoconazole is an imidazole ring containing antifungal agent used in the treatment of systemic fungal infections. It acts by blocking the synthesis of ergosterol, an essential component of the fungal cell membrane. OBJECTIVE The… read more here.
Keywords: formulation; release; hyaluronic acid; ketoconazole ... See more keywords
Simultaneous improvement of ketoconazole solubility, antifungal and antibiofilm activity by multicomponent complexation.
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DOI: 10.4155/tde-2020-0053
Abstract: Background: A novel multicomponent complex (MC) of ketoconazole (KET) with β-cyclodextrin (β-CD) and N-acetylcysteine (NAC) was developed with the purpose of improving the solubility as well as the antifungal and antibiofilm activity of KET against… read more here.
Keywords: antifungal antibiofilm; ketoconazole; solubility; multicomponent ... See more keywords